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Table 5 Hemodynamics during a water deprivation test in patients with adult dominant polycystic kidney disease (ADPKD), patients with non-ADPKD kidney disease (Non-ADPKD), and healthy control subjects (Controls)

From: Urine concentration ability is reduced to the same degree in adult dominant polycystic kidney disease compared with other chronic kidney diseases in the same CKD-stage and lower THAN in healthy control subjects - a CASE control study

 

08.30 AM-09-30 AM

09.30 AM–10.30 AM

10.30 AM–11.30 AM

11.30 AM-12.30 PM

Systolic bBP (mm Hg)

 ADPKD

129 ± 9*#

131 ± 9*#

133 ± 11*#

131 ± 12*

 Non-ADPKD

122 ± 14*

124 ± 16*

125 ± 16*

126 ± 18*

 Controls

113 ± 12

117 ± 12

118 ± 14

120 ± 16

Comparison within groups

0.282

Comparison between groups

0.004

Diastolic bBP (mm Hg)

 ADPKD

83 ± 9*#

84 ± 9*#

84 ± 9*#

84 ± 10*#

 Non-ADPKD

77 ± 9

76 ± 10

77 ± 11

77 ± 11

 Controls

74 ± 9

74 ± 10

76 ± 11

76 ± 11

Comparison within groups

0.394

Comparison between groups

< 0.001

MAP (mm Hg)

 ADPKD

104 ± 8*#

106 ± 9*#

107 ± 9*#

106 ± 10*#

 Non-ADPKD

98 ± 11*

98 ± 12

99 ± 13

100 ± 14

 Controls

92 ± 10

94 ± 11

95 ± 12

96 ± 13

Comparison within groups

0.268

Comparison between groups

< 0.001

HR (beats/ min)

 ADPKD

60 ± 10*

62 ± 11*

62 ± 11*

64 ± 11*

 Non-ADPKD

59 ± 8

60 ± 7*

61 ± 8*

62 ± 8*

 Controls

57 ± 6

57 ± 6

58 ± 7

59 ± 7

Comparison within groups

0.250

Comparison between groups

0.029

Systolic cBP (mmHg)

 ADPKD

119 ± 11*#

122 ± 11*#

123 ± 13*#

122 ± 14*

 Non-ADPKD

112 ± 14*

114 ± 15

115 ± 15

117 ± 17

 Controls

106 ± 12

110 ± 13

111 ± 13

113 ± 15

Comparison within groups

0.195

Comparison between groups

< 0.001

Diastolic cBP (mm Hg)

 ADPKD

84 ± 9*#

85 ± 9*#

86 ± 9*#

85 ± 10*#

 Non-ADPKD

78 ± 10

76 ± 10

78 ± 11

78 ± 12

 Controls

74 ± 10

75 ± 11

76 ± 10

76 ± 11

Comparison within groups

0.710

Comparison between groups

< 0.001

AIx (%)

 ADPKD

31 ± 13

28 ± 13

31 ± 13

28 ± 13

 Non-ADPKD

31 ± 16

31 ± 16

29 ± 17

29 ± 15

 Controls

31 ± 12

32 ± 14

29 ± 13

28 ± 14

Comparison within groups

0.645

Comparison between groups

0.903

PWV (m/s)

 ADPKD

8 ± 2

8 ± 2

8 ± 2

8 ± 2

 Non-ADPKD

8 ± 2

8 ± 2

8 ± 2

8 ± 2

 Controls

8 ± 2

8 ± 2

8 ± 2

8 ± 2

Comparison within groups

0.124

Comparison between groups

0.819

  1. A General Linear Model with Greenhouse-Geisser correction was used for comparison within and between the three groups. Values represent mean ± SD or median with 25 and 75% percentiles in brackets * = p < 0.05 between ADPKD or non-ADPKD patients and healthy controls. # = p < 0.05 between ADPKD and non-ADPKD patients
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BMC Nephrology

ISSN: 1471-2369

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