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Table 5 Hemodynamics during a water deprivation test in patients with adult dominant polycystic kidney disease (ADPKD), patients with non-ADPKD kidney disease (Non-ADPKD), and healthy control subjects (Controls)

From: Urine concentration ability is reduced to the same degree in adult dominant polycystic kidney disease compared with other chronic kidney diseases in the same CKD-stage and lower THAN in healthy control subjects - a CASE control study

  08.30 AM-09-30 AM 09.30 AM–10.30 AM 10.30 AM–11.30 AM 11.30 AM-12.30 PM
Systolic bBP (mm Hg)
 ADPKD 129 ± 9*# 131 ± 9*# 133 ± 11*# 131 ± 12*
 Non-ADPKD 122 ± 14* 124 ± 16* 125 ± 16* 126 ± 18*
 Controls 113 ± 12 117 ± 12 118 ± 14 120 ± 16
Comparison within groups 0.282
Comparison between groups 0.004
Diastolic bBP (mm Hg)
 ADPKD 83 ± 9*# 84 ± 9*# 84 ± 9*# 84 ± 10*#
 Non-ADPKD 77 ± 9 76 ± 10 77 ± 11 77 ± 11
 Controls 74 ± 9 74 ± 10 76 ± 11 76 ± 11
Comparison within groups 0.394
Comparison between groups < 0.001
MAP (mm Hg)
 ADPKD 104 ± 8*# 106 ± 9*# 107 ± 9*# 106 ± 10*#
 Non-ADPKD 98 ± 11* 98 ± 12 99 ± 13 100 ± 14
 Controls 92 ± 10 94 ± 11 95 ± 12 96 ± 13
Comparison within groups 0.268
Comparison between groups < 0.001
HR (beats/ min)
 ADPKD 60 ± 10* 62 ± 11* 62 ± 11* 64 ± 11*
 Non-ADPKD 59 ± 8 60 ± 7* 61 ± 8* 62 ± 8*
 Controls 57 ± 6 57 ± 6 58 ± 7 59 ± 7
Comparison within groups 0.250
Comparison between groups 0.029
Systolic cBP (mmHg)
 ADPKD 119 ± 11*# 122 ± 11*# 123 ± 13*# 122 ± 14*
 Non-ADPKD 112 ± 14* 114 ± 15 115 ± 15 117 ± 17
 Controls 106 ± 12 110 ± 13 111 ± 13 113 ± 15
Comparison within groups 0.195
Comparison between groups < 0.001
Diastolic cBP (mm Hg)
 ADPKD 84 ± 9*# 85 ± 9*# 86 ± 9*# 85 ± 10*#
 Non-ADPKD 78 ± 10 76 ± 10 78 ± 11 78 ± 12
 Controls 74 ± 10 75 ± 11 76 ± 10 76 ± 11
Comparison within groups 0.710
Comparison between groups < 0.001
AIx (%)
 ADPKD 31 ± 13 28 ± 13 31 ± 13 28 ± 13
 Non-ADPKD 31 ± 16 31 ± 16 29 ± 17 29 ± 15
 Controls 31 ± 12 32 ± 14 29 ± 13 28 ± 14
Comparison within groups 0.645
Comparison between groups 0.903
PWV (m/s)
 ADPKD 8 ± 2 8 ± 2 8 ± 2 8 ± 2
 Non-ADPKD 8 ± 2 8 ± 2 8 ± 2 8 ± 2
 Controls 8 ± 2 8 ± 2 8 ± 2 8 ± 2
Comparison within groups 0.124
Comparison between groups 0.819
  1. A General Linear Model with Greenhouse-Geisser correction was used for comparison within and between the three groups. Values represent mean ± SD or median with 25 and 75% percentiles in brackets * = p < 0.05 between ADPKD or non-ADPKD patients and healthy controls. # = p < 0.05 between ADPKD and non-ADPKD patients
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BMC Nephrology

ISSN: 1471-2369

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