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Fig. 2 | BMC Nephrology

Fig. 2

From: NMDA receptor-mediated CaMKII/ERK activation contributes to renal fibrosis

Fig. 2

NR1 knockdown partially reversed the increased expression levels of fibrotic markers in UUO kidneys. a Masson’s trichrome staining of kidneys, immunohistochemical staining of fibronectin, α-SMA, and S100A4 (A1), and quantitative analysis (A2) from the control (Con) group, UUO group, UUO + NR1-targeting shRNA-transfected (NR1-sh) group, and UUO + scrambled shRNA transfected (Scr-sh) group. b Western blot analysis of fibronectin, COL1A1, α-SMA, and S100A4 COL1A1 (B1) and quantitative analysis (B2) (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001 versus the Con group; #P < 0.05, ##P < 0.01, ###P < 0.001 versus the UUO group; P < 0.01, P < 0.001 versus the UUO + NR1-sh group. Representative images from each group (original magnification: × 200; scale bar = 100 μm)

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