Fig. 4

aIRRs for each combination of the values at baseline and 12 months later. Levels of each parameter were divided into three categories (L, M and H); the middle category were defined as 4.0–7.0 mg/dL for phosphorus, 8.5–9.5 mg/dL for calcium and 200–500 pg/mL for intact PTH. For each 12-month interval ending at visit t, the changing patterns of MBD parameters during the previous 12-month interval from visit t—2 (baseline) to visit t—1 (12 months later) were evaluated. Incidence rate ratios were adjusted for patients’ characteristics (age, sex, primary kidney disease, diabetes, dialysis vintage, cardiovascular disease, lung disease, liver disease, malignancy and history of parathyroidectomy) and time-varying variables (VDRAs, phosphate binders, cinacalcet, albumin, hemoglobin, body mass index, Kt/V and dialysate Ca concentration). aIRRs, adjusted incident rate ratios; H, high; PTH, parathyroid hormone; L, low; M, middle; MBD, mineral and bone disorder; ref, reference; VDRA, vitamin D receptor activator