Changes in 3-month mineral and bone disorder patterns were associated with all-cause mortality in prevalent hemodialysis patients with secondary hyperparathyroidism

Table 2 aIRs of mortality for patients whose parameters were maintained in the same category during the 3-month intervals

	Adjusted incidence rates [95% CI], /100 person-years
	L-L group	M-M group	H–H group
P	7.4 [5.4–9.4]	4.9 [4.4–5.3]	11.1 [6.4–15.7]
Ca	3.7 [1.5–5.8]	4.5 [3.9–5.2]	6.8 [6.1–7.5]
iPTH	5.9 [5.3–6.5]	5.4 [4.7–6.1]	6.7 [4.1–9.3]

Levels of each parameter were divided into three categories (L, M and H); the middle category were defined as 4.0–7.0 mg/dL for P, 8.5–9.5 mg/dL for Ca and 200–500 pg/mL for iPTH. For each 3-month interval ending at visit t, the changing patterns of MBD parameters during the previous 3-month interval from visit t—2 (baseline) to visit t—1 (3 months later) were evaluated. Incidence rates were adjusted for patients’ characteristics (age, sex, primary kidney disease, diabetes, dialysis vintage, cardiovascular disease, lung disease, liver disease, malignancy and history of parathyroidectomy) and time-varying variables (VDRAs, phosphate binders, cinacalcet, albumin, hemoglobin, body mass index, Kt/V and dialysate Ca concentration)
aIRs Adjusted incident rates, Ca Calcium, H High, iPTH Intact parathyroid hormone, L low, M Middle, MBD Mineral and bone disorder, P Phosphorus, VDRA Vitamin D receptor activator

ISSN: 1471-2369