Table 3 Clinical and pathological features of AITL with kidney involvement

1

Wood [20]

1979

76

M

Yes

N/A

Negative

Coomb’s test

AKI, nephritic syndrome

Minor glomerular change with diffuse podocyte effacement and “full house” pattern of Igs and C3/C4 deposition

Glucocorticoid and CTX

Deceased

2

Wood [20]

1979

79

M

Yes

N/A

N/A

Coomb’s test

AKI, nephritic syndrome

Diffuse granular IgM deposition in the glomerulus

Hemodialysis

Deceased

3

Plazer [21]

1981

64

M

Unclear^*

Unclear^*

Unclear^*

Unclear^*

Kidney failure

Interstitial nephritis

High dose prednisone

Clinical remission

4

Bhat [22]

1981

77

F

Yes

Urinary kappa light chain

Negative

ANA

Kidney dysfunction

Cast nephropathy, minor glomerular change

No specific treatment

Deceased

5

Resegotti [23]

1983

72

F

Yes

N/A

N/A

N/A

Nephritic syndrome, kidney failure

Lymphoplasmacytic infiltration in the kidney

Melphalan, vincristine, prednisone

Deceased

6

Bello [24]

1985

61

M

Yes

N/A

N/A

Coomb’s test

Fanconi syndrome

not performed

Hydrocortisone

Clinical remission

7

Bignon [25]

1986

70

M

Yes

Negative

Negative

Negative

Proteinuria, kidney failure

Lymphoplasmacytic infiltration in the interstitium

N/A

N/A

8

Staszewski [26]

1988

58

M

Yes

Negative

Negative

Negative

NS, normal kidney function

MCD

No specific treatment

Spontaneous remission

9

Yamazaki [27]

1991

72

M

Unclear^**

Unclear^**

Unclear^**

Unclear^**

kidney failure

EPGN

vincristine, prednisolone

Deceased

10

Nakamoto [28]

1993

40

M

Yes

Negative

Negative

Coomb’s test

Nephritic syndrome, kidney dysfunction

Interstitial nephritis

CTX, prednisone

Complete remission

11

Duwaji [29]

1995

71

M

Yes

Negative

Positive

Cold agglutinin

AKI

Diffuse proliferative GN

Pulse steroid and CTX, then doxorubicin, CTX, etoposide and vincristine

Deceased

12

Lim [30]

1998

35

M

Yes

N/A

Negative

ANA

NS

AA amyloidosis

CTX, pirarubicin, vincristine, and prednisone

Partial remission of NS

13

Hamidou [31]

2001

65

M

Yes

N/A

Negative

C-ANCA

Nephritic syndrome, kidney failure

N/A

CHOP

Deceased

14

Goto [32]

2004

73

M

Yes

N/A

N/A

N/A

Kidney dysfunction

Diffuse parenchymal infiltration

N/A

N/A

15

De Samblanx [33]

2004

67

M

Yes

Urinary kappa light chain

Negative

C-ANCA

NS, kidney dysfunction

Proliferative GN

Pulse MP + CHOP

Partial remission of NS

16

Miura [34]

2006

70

M

Yes

Serum IgMλ

Positive

Negative

AKI, microscopic hematuria

Cryoglobulinemic MPGN,

Pulse MP + CHOP

Partial remission

17

Argov [35]

2009

46

M

Yes

N/A

N/A

N/A

Kidney dysfunction with normal urinalysis

Giant kidneys, diffuse leukocyte infiltration and parenchymal effacement

CTX, doxorubicin, vincristine, and prednisone

Kidney size shrinkage with improved renal function

18

Togashi [36]

2010

21

M

no

N/A

N/A

Coomb’s test

NS with normal kidney function

MN

CHOP

Complete remission

19

Ambrosio [9]

2012

40

M

Yes

N/A

N/A

Negative

Incidental renal mass, normal kidney function

Unilateral kidney infarction, polyarteritis nodosa lesion in the left kidney

Pegylated liposomal doxorubicin, cytarabine, dexamethasone and nephrectomy of the affected kidney

Partial remission

20

Nanno [37]

2013

30

F

Unclear^**

Unclear^**

Unclear^**

Unclear^**

NS

EPGN

CHOP

Partial remission

21

Harada [38]

2017

79

M

Yes

Serum IgMλ

Positive

ANA, Coomb’s test

Nephritic syndrome, kidney dysfunction

IgA nephropathy

CTX, pirarubicin, vincristine, and prednisone

Complete remission

22

Present case

–

67

F

Yes

Skewed serum κ/λ

Negative

ANA, ACL, Coomb’s test

AKI, nephritic syndrome

DPGN

MP, RTX and PE then CHOP

Initial remission then relapse