Table 1 Summary of previously reported cases of M.abscessus PD peritonitis
Case number | Age: sex | Duration of PD | Time to culture | Positive AFB stain | Removal of PD catheter | Antibiotics and duration | Clinical outcome | Prior ESI, TI or abdominal intervention prior. | Country of reported case |
|---|---|---|---|---|---|---|---|---|---|
1 [14] | 67 M | 12 months | Y | Amikacin, Clarithromycin (3 months) | Converted to HD | USA | |||
2 [12] | 70 M | 36 months | 9 days | N | Y | Amikacin, Clarithromycin Clarithromycin stopped (hepatic impairment) | Converted to HD. Died 6 weeks into treatment, acute coronary syndrome. | Y - Umbilical hernia repair | China |
3 [12] | 50 M | 6 months | 6 days | N | Y | Ciprofloxacin, Clarithromycin (3 months) | Converted to HD | Y – culture negative ESI | India |
4 [12] | 56 M | 36 months | 8 days | N | Y | Amikacin, Clarithromycin | Converted to HD. Re-admission with catheter related infection and sepsis 2 weeks after discharge. Died from acute coronary syndrome. | Y- Pseudomonas ESI | China |
5 [12] | 60 M | 46 months | 6 days | Y | Y | Amikacin (6 weeks) Clarithromycin (3 months) Amikacin stopped as developed sensorineural hearing loss. | Temporarily converted to HD. Re-established on PD after 3 months. | N | China |
6 [15] | 60F | 60 months | 6 days | Y | Y | Amikacin, Clarithromycin (8 weeks) | Converted to HD | Y – accidental removal of Tenckhoff catheter | Saudi |
7 [15] | 64F | 12 months | 4 days | Y | Y | Clarithromycin (12 weeks) | Converted to HD | N | Saudi |
8 [16] | 39F | 60 months | Not disclosed | Not disclosed | Y | Meropenem (4 weeks), Amikacin (8 weeks), Cefoxitin (28 weeks) | Converted to HD. Intra-abdominal collection requiring drainage. | Recurrent P.aeruginosa ESI 2004–2007 | Hong Kong |
9 [16] | 45 M | 3 months | Not disclosed | Not disclosed | Y | Amikacin (4 weeks), Azithromycin 6 weeks) Moxifloxacin (20 weeks) | Temporarily converted to HD. Re-established on PD after 9 months. | N | Hong Kong |
10 [17] | 49 M | Not disclosed | Not disclosed | Not disclosed | Y | Cephazolin, Gentamicin | Converted to HD. Died after 5 months (sclerosing peritonitis) | Australia | |
11 [17] | 40F | Not disclosed | Not disclosed | Not disclosed | Y | Amikacin, Cefoxitin, Vancomycin, Gentamicin, Flucloxacillin | Converted to HD | Australia | |
12 [17] | 65 M | Not disclosed | Not disclosed | Not disclosed | Y | Clarithromycin, Vancomycin, Ticarcillin and clavulanic acid, Gentamicin | Converted to HD | Australia | |
13 [18] | 44F | 96 months | 28 days | Y | Y | Clarithromycin (165 days), Amikacin (68 days), Meropenem (165 days), Levofloxacin (111 days) | Converted to HD. Died after 8 months (renal haemorrhage and retroperitoneal infection). | Y – Catheter replacement for refractory exit site infection. Commenced on anti-tuberculous drugs post AFB. | Taiwan |
14 [18] | 58F | 60 months | 10 days (treatment commenced day 3) | Y | Y | Clarithromycin (165 days), Amikacin (50 days), Imipenem (70 days), Ciprofloxacin (217 days), Doxycycline (180 days). | Converted to HD. Abscess formation in abdominal wall requiring debridement × 2. | Y – Catheter replacement 3 weeks prior for tunnelled line infection. | Taiwan |
15 [11] | 51F | 14 months | Not disclosed | Y | Y | Clarithromycin (7 weeks) Ciprofloxacin (3 weeks) Amikacin (3 weeks) | Converted to HD. Disseminated cutaneous infection requiring surgical debridement | Y – PD catheter replacement 8 days prior (persistent culture neg. Tunnel infection) | Japan |
16 [19] | 56 M | 33 days | N | Y | Imipenem (4 weeks) Clarithromycin (6 months) | Converted to HD. Infection post catheter insertion. | Y – Re-insertion of PD catheter (refractory ESI and TI presumed to be methicillin resistant coagulase negative staphylococcus) | Japan |