Table 3 Pathology features in different SIS groups

 Activity index

4 (3, 5)

3 (2, 4)

3 (2, 4)

4 (4, 5)*^#

< 0.001

 Interstitial edema

1 (0, 1)

1 (0, 1)

1 (0, 1)

1 (1, 1)*

0.044

 Interstitial inflammation

3 (2, 4)

2 (2, 3)

2 (2, 3)

4 (3, 4)*^#

< 0.001

 Tubulitis

0 (0, 0)

0 (0, 1)

0 (0, 1)

0 (0, 0)

0.218

 Chronicity index

1 (0, 2)

1 (0, 3)

0 (0, 2)

1 (0, 2)

0.438

 Interstitial fibrosis

0 (0, 1)

0 (0, 2)

0 (0, 2)

0 (0, 0)*

0.030

 Tubular atrophy

0 (0, 2)

1 (0, 2)

0 (0, 1)

1 (0, 2)

0.629

 Total cells^a

391.5 ± 135.5

294.8 ± 145.4

378.2 ± 97.8

450.4 ± 124.0*

0.001

 T lymphocytes

173.9 ± 63.6

137.6 ± 72.3

170.5 ± 64.0

195.5 ± 50.08*

0.019

 B lymphocytes

45.4 (30.4, 62.0)

34.7 (14.4, 41.6)

45.6 (30.7, 60.4)

56.4 (40.1, 69.1)*

0.040

 Monocytes/macrophages

101.8 ± 34.8

77.6 ± 35.9

90.7 ± 30.5

121.6 ± 24.9*^#

< 0.001

 Plasma cells

43.8 ± 24.3

30.3 ± 20.7

32.6 ± 19.3

57.9 ± 21.7*^#

< 0.001

 Neutrophils

15.4 (4.9, 33.0)

2.9 (1.7, 13.8)

7.9 (4.7, 20.4)

31.7 (15.7, 48.8)*^#

< 0.001

 Eosinophils^b

2.1 (0.5, 5.1)

0.4 (0.1, 1.7)

0.8 (0.0, 1.9)

3.8 (2.2, 9.0) *^#

< 0.001

 T lymphocytes

44.3 ± 9.0

46.9 ± 8.5

46.1 ± 10.1

41.7 ± 8.2

0.136

 B lymphocytes

11.7 (9.1, 14.2)

10.6 (8.8, 14.5)

12.6 (9.4, 14.9)

11.5 (8.7, 14.0)

0.263

 Monocytes/macrophages

26.0 (21.3, 29.9)

25.8 (21.5, 30.9)

26.2 (23.4, 29.1)

0.670

 Plasma cells

10.9 ± 5.2

9.4 ± 4.4

9.2 ± 5.7

12.6 ± 4.9*^#

0.047

 Neutrophils

4.2 (1.6, 7.8)

1.1 (0.9, 5.4)

2.4 (1.7, 4.8)

7.5 (4.3, 11.7)*^#

< 0.001