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Table 4 Treatment and renal outcome in different SIS groups

From: Elevation of erythrocyte sedimentation rate and C-reactive protein levels reflects renal interstitial inflammation in drug-induced acute tubulointerstitial nephritis

Variables

Total

N = 81

Low-SIS

N = 23

Medium-SIS

N = 24

High-SIS

N = 34

P-value

Immunosuppressive treatment, n (%)

 Prednisone only

52 (64.2)

19 (82.6)

15 (62.5)

18 (52.9)

0.071

 Methylprednisolone pulse therapy

18 (22.2)

0 (0)

6 (25.0)*

12 (35.3)*

0.007

 Immunosuppressive medications

22 (27.2)

4 (17.4)

8 (33.3)

10 (29.4)

0.436

Renal recovery at 6 months post-biopsy, n(%)

 Complete

52 (64.2)

15 (65.2)

12 (50.0)

25 (73.5)

0.195

 Partial

28 (34.6)

7 (30.4)

12 (50.0)

9 (26.5)

 

 None

1 (1.2)

1 (4.3)

0 (0)

0 (0)

 

Renal outcome evaluated by eGFR (mL/min/1.73 m2)

 ≥ 60

47 (58.0)

16 (69.6)

8 (33.3)*

18 (67.6)#

0.014

 < 60

28 (42.0)

7 (30.4)

16 (66.7)

11 (32.4)

  1. Abbreviations: SIS systemic inflammatory score; eGFR estimated glomerular filtration rates; CKD chronic kidney disease; CRP C reactive protein; ESR erythrocyte sedimentation rate
  2. *: compared with low-SIS group, P < 0.05; #: compared with medium-SIS group, P < 0.05