Table 2 Regression models of the relationship between annual decline in eGFR and baseline concentrations of measures of liver function tests and full blood count indices
Baseline factor | unadjusted | Adjusted for age and gender | Adjusted for age, gender and UACR | Adjusted for age gender, UACR and diabetes | Adjusted for age, gender, UACR, diabetes, total cholesterol, triglycerides, BMI, WHR, Alcohol consumption | |||||
|---|---|---|---|---|---|---|---|---|---|---|
β (95% CI) | p-value | β (95%CI) | p-value | β (95% CI) | p-value | β (95% CI) | p-value | β (95% CI) | p-value | |
Log ALT (U/L) | 0.55 (−0.52–1.62) | 0.315 | 0.66 (− 0.45–1.77) | 0.245 | 0.56 (− 0.54–1.67) | 0.315 | 0.55 (− 0.57–1.67) | 0.336 | − 0.06 (−1.16–1.04) | 0.914 |
Log GGT (U/L) | − 0.45 (−1.17–0.27) | 0.224 | − 0.39 (− 1.13–0.34) | 0.295 | −0.18 (− 0.92–0.56) | 0.636 | −0.07 (− 0.83–0.69) | 0.857 | −0.18 (− 0.94–0.59) | 0.655 |
Log ALP (U/L) | − 0.98 (−2.58–0.61) | 0.226 | −1.05 (−2.65–0.56) | 0.200 | −0.04 (− 1.67–0.60) | 0.966 | 0.12 (− 1.55–1.77) | 0.897 | 0.38 (− 1.26–2.02) | 0.639 |
Log Bilirubin (μmol/L) | − 0.27 (− 1.28–0.74) | 0.599 | −0.17 (− 1.21–0.86) | 0.742 | −1.00 (− 2.07–0.07) | 0.067 | −1.04 (− 2.13–0.06) | 0.063 | −1.43 (− 2.52- -0.33) | 0.010 |
Serum albumin (g/L) | 0.34 (0.22–0.46) | < 0.001 | 0.36 (0.24–0.49) | < 0.001 | N/A | N/A | 0.34 (0.21–0.47)a | < 0.001 | 0.31 (0.18–0.44)a | < 0.001 |
Hb (g/L) | 0.04 (0.01–0.07) | 0.007 | 0.06 (0.03–0.10) | 0.001 | 0.05 (0.01–0.08) | 0.014 | 0.04 (0.01–0.08) | 0.018 | 0.013 (−0.02–0.05) | 0.011 |
WBC (× 109/L) | 0.03 (−0.14–0.20) | 0.720 | 0.03 (−0.14–0.20) | 0.739 | 0.08 (− 0.09–0.25) | 0.354 | 0.07 (− 0.10–0.24) | 0.404 | 0.02 (− 0.15–0.19) | 0.797 |
RBC (× 1012/L) | 0.14 (− 0.24–0.51) | 0.483 | 0.17 (− 0.22–0.56) | 0.391 | 0.15 (− 0.24–0.54) | 0.456 | 0.14 (− 0.26–0.53) | 0.493 | −0.04 (− 0.45–0.36) | 0.832 |