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Table 1 Demographic and Clinical Characteristics of the study population

From: Diagnostic performance of glomerular PLA2R and THSD7A antibodies in biopsy confirmed primary membranous nephropathy in South Africans

 

PMN

(n = 41)

LN-V

(n = 19)

DN

(n = 28)

p-value

Total

(n = 88)

Age (years)

44.5 ± 17.5

33.8 ± 13.9

46.8 ± 14.2

0.02

42.9 ± 16.4

Female gender [n (%)]

25 (61.0)

17 (89.5)

18 (64.3)

0.07

60 (68.2)

Race (Black) [n (%)]

13 (31.7)

7 (36.8)

9 (32.1)

0.92

29 (32.9)

mABP (mmHg)

94.6 ± 11.7

85.7 ± 8.0

99.4 ± 16.1

0.01

94.3 ± 13.4

Presence of oedema [n (%)]

26 (89.7)

8 (53.3)

16 (64.0)

0.02

50 (72.5)

Hb (g/dL)

11.8 ± 2.1

10.6 ± 2.3

9.9 ± 1.7

0.001

11.0 ± 2.2

Platelet count (x109/L)

368.4 ± 129.2

307.4 ± 149.4

340.9 ± 137.1

0.34

348.3 ± 135.7

WBC count (x109/L)

8.4 ± 2.4

8.5 ± 4.6

9.0 ± 3.2

0.76

8.6 ± 3.1

Total cholesterol (mmol/L)

9.3 (7.8–11.6)

4.6 (3.7–5.8)

6.3 (4.8–7.9)

0.001

7.8 (5.5–9.6)

Serum albumin (g/L)

21.8 ± 7.1

25.4 ± 7.4

28.0 ± 5.9

0.004

24.3 ± 7.3

UPCR (g/mmol creatinine)

0.87 (0.49–1.26)

0.54 (0.27–0.75)

0.52 (0.17–1.34)

0.07

0.72 (0.34–1.24)

Serum creatinine (µmol/L)

80 (63–103)

72 (51–123)

188 (97–471)

0.001

96 (66–167)

eGFR (mL/min/1.73 m2)

85 (57–124)

98 (49–137)

30 911 − 63)

0.001

68 (38–111)

  1. PMN Primary membranous nephropathy, LN-V class V lupus nephritis, DN diabetic nephropathy, mABP Mean Arterial Blood Pressure, Hb Haemoglobin, WBC White Blood Cell, UPCR Urine Protein Creatinine Ratio, eGFR estimated glomerular filtration rate
  2. The 24-hour value of proteinuria (g/24Hrs) is approximately 10-times the ratio of the UPCR in g/mmol creatinine