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Table 4 Summary of studies regarding application of the Oxford classification to patients with Henoch-Schönlein purpura nephritis

From: MEST-C pathological score and long-term outcomes of child and adult patients with Henoch-Schönlein purpura nephritis

StudyNo. of patientsAgeDefinition of renal outcomeSignificant pathologic parameters
Univariate modelMultivariate model
Child patients
 Çakıcı et el. (2019) [17]75< 18 years< 90 mL/min/1.73 m2 or 50% decrease of eGFR; or persistent PU/HUS1, T1/T2T1/T2b
 Xu et el. (2018) [18]104< 18 years< 90 mL/min/1.73 m2 or 50% decrease of eGFRS1Nonec
 The present study113< 18 yearsESRD or doubling of sCrM1, T1/T2M1, T1/T2
Adult patients
 Inagaki et el. (2018) [16]74≥18 yearsESRD or 30% decrease of eGFRE1E1d
 Kim et el. (2014)a [19]61≥16 yearsESRD; or < 60 mL/min/1.73 m2 or ≥ 30% decrease of eGFRE1, T1/T2, CaE1, T1/T2e
 The present study100≥18 yearsESRD or doubling of sCrT1/T2T1/T2
  1. ESRD end-stage renal disease, sCr serum creatinine, eGFR estimated glomerular filtration rate, PU proteinuria, HU hematuria
  2. aCrescent formation was defined when crescents were ≥ 50% of the glomeruli, which differs from the updated Oxford classification (C1: 0–25%; C2: ≥25%)
  3. bAdjusted for E, S, T, and estimated glomerular filtration rate
  4. cAdjusted for M, E, S, T, and C
  5. dAdjusted for E, T, C, age, sex, and proteinuria
  6. eAdjusted for E, T, C, hypertension, proteinuria, and estimated glomerular filtration rate
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