MEST-C pathological score and long-term outcomes of child and adult patients with Henoch-Schönlein purpura nephritis

Table 4 Summary of studies regarding application of the Oxford classification to patients with Henoch-Schönlein purpura nephritis

Study	No. of patients	Age	Definition of renal outcome	Significant pathologic parameters
Study	No. of patients	Age	Definition of renal outcome	Univariate model	Multivariate model
Child patients
Çakıcı et el. (2019) [17]	75	< 18 years	< 90 mL/min/1.73 m² or 50% decrease of eGFR; or persistent PU/HU	S1, T1/T2	T1/T2^b
Xu et el. (2018) [18]	104	< 18 years	< 90 mL/min/1.73 m² or 50% decrease of eGFR	S1	None^c
The present study	113	< 18 years	ESRD or doubling of sCr	M1, T1/T2	M1, T1/T2
Adult patients
Inagaki et el. (2018) [16]	74	≥18 years	ESRD or 30% decrease of eGFR	E1	E1^d
Kim et el. (2014)^a [19]	61	≥16 years	ESRD; or < 60 mL/min/1.73 m² or ≥ 30% decrease of eGFR	E1, T1/T2, C^a	E1, T1/T2^e
The present study	100	≥18 years	ESRD or doubling of sCr	T1/T2	T1/T2

ESRD end-stage renal disease, sCr serum creatinine, eGFR estimated glomerular filtration rate, PU proteinuria, HU hematuria
^aCrescent formation was defined when crescents were ≥ 50% of the glomeruli, which differs from the updated Oxford classification (C1: 0–25%; C2: ≥25%)
^bAdjusted for E, S, T, and estimated glomerular filtration rate
^cAdjusted for M, E, S, T, and C
^dAdjusted for E, T, C, age, sex, and proteinuria
^eAdjusted for E, T, C, hypertension, proteinuria, and estimated glomerular filtration rate

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