Biochemical and histopathological changes in Wistar rats after consumption of boiled and un-boiled water from high and low disease prevalent areas for chronic kidney disease of unknown etiology (CKDu) in north Central Province (NCP) and its comparison with low disease prevalent Colombo, Sri Lanka

Table 2 Microalbumin:creatinine ratios and other biochemical parameters after 8 and 14 months of experimental period

Bio Chemical Parameter	Unit	NTM	NTMB	DD	BB	HW	CO
Serum creatinine	[mg/dL]	0.80 ± 0.03	0.80 ± 0.04	0.85 ± 0.03	0.86 ± 0.02	0.79 ± 0.04	0.76 ± 0.04
BUN	[mg/dL]	36.37 ± 1.36	36.37 ± 1.36	39.42 ± 2.74	36.54 ± 3.53	32.88 ± 1.68	35.27 ± 0.896
Microalbumin:creatinine	[mg/g]	140.28 ± 28.29	59.35 ± 5.05	67.39 ± 8.09	30.23 ± 9.48	70.03 ± 11.62	19.08 ± 7. 14
AST	[U/L]	97.8 ± 7.5	92.3 ± 6.0	93.6 ± 16.1	101.0 ± 5.5	175.8 ± 23.1	88.41 ± 16.37
ALT	[U/L]	39 ± 4.5	42 ± 4.5	32.2 ± 8.1	40.6 ± 2.5	123.4 ± 30.5	40.88 ± 18.33
Histology (non-affected / affected)	%	0.46 ± 0.18	0.28 ± 0.07	0.48 ± 0.14	0.31 ± 0.07	0.39 ± 0.14	1.0

NTM New Town Medirigiriya, NTMB New Town Medirigiriya Boiled, DD Divuldamana, BB Bisobandaragama, HW Huruluwewa, CO Colombo. Values are expressed as a mean ± SEM (n = 60).

ISSN: 1471-2369