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Table 4 Comparison of laboratory data according to the location of immunofluorescence deposits at diagnosis

From: Immunofluorescence deposits in the mesangial area and glomerular capillary loops did not affect the prognosis of immunoglobulin a nephropathy except C1q:a single-center retrospective study

Parameter

N

Hemoglobin (g/L)

Serum

albumin (g/L)

eGFR

(ml/min/1.73m2)

Scr

(μmol/L)

TG

(mmol/L)

CHOL (mmol/L)

Serum

IgA (g/L)

Serum

IgG (g/L)

Serum

IgM (g/L)

Serum

C3 (g/L)

Proteinuria

(g/24 h)

IgA

Mesangial-only

251

130.1 ± 18.1

37.7 (33.7,41.1)

92.4 ± 31.9

78.2 (59.2,78.2)

1.9 ± 2.1

5.1 ± 2.2

2.7 ± 1.1

10.4 ± 3.3

1.4 ± 0.7

1.0 ± 0.3

0.5 (0.3,1.5)

 

Mesangial +GCLs

86

130.9 ± 19.2

36.7 (31.3,40.5)

92.3 ± 33.3

80.2 (62.1,103.0)

2.0 ± 1.9

5.5 ± 2.2

2.8 ± 1.1

9.8 ± 3.2*

1.3 ± 0.6

1.0 ± 0.2

1.1 (0.5,1.9) *

 

P

 

0.925

0.276

0.754

0.454

0.607

0.077

0.896

0.048

0.266

0.125

< 0.001

IgG

(−)

258

130.3 ± 18.6

37.6 (33.7,41.1)

91.3 ± 31.2

79.3 (60.3,102.8)

2.0 ± 2.3

5.3 ± 2.3

2.7 ± 1.1

10.2 ± 3.2

1.4 ± 0.7

1.0 ± 0.3

0.6 (0.3,1.6)

 

Mesangial-only

32

132.4 ± 18.7

37.9 (34.1,40.6)

101.6 ± 34.5

73.0 (58.4,92.3)

1.4 ± 0.8

4.6 ± 2.0

2.9 ± 1.2

11.0 ± 3.2

1.5 ± 0.8

0.9 ± 0.3

0.4 (0.2,0.7)

 

Mesangial +GCLs

33

128.5 ± 17.2

35.8 (28.8,41.3)

94.9 ± 37.6

70.6 (59.5,95.6)

1.7 ± 1.3

5.6 ± 2.0b

2.8 ± 1.2

9.9 ± 3.6

1.4 ± 0.7

1.0 ± 0.2

1.2 (0.4,3.1) b

 

P

 

0.646

0.758

0.382

0.289

0.325

0.044

0.488

0.406

0.742

0.157

0.008

IgM

(−)

199

129.0 ± 18.4

37.6 (33.7,41.1)

89.7 ± 32.0

80.5 (62.6,102.8)

1.7 ± 1.5

5.1 ± 2.1

2.6 ± 1.0

10.2 ± 3.2

1.2 ± 0.6

1.0 ± 0.2

0.6 (0.3,1.6)

 

Mesangial-only

102

132.8 ± 17.6

36.4 (32.6,41.2)

97.9 ± 32.2

72.2 (58.3,95.4)

2.4 ± 3.0

5.4 ± 2.5

2.8 ± 1.1

10.2 ± 3.3

1.6 ± 0.8a

1.1 ± 0.3

0.6 (0.3,1.5)

 

Mesangial +GCLs

35

130.8 ± 20.2

37.1 (33.7,40.6)

92.5 ± 32.3

74.3 (59.9,103.3)

1.8 ± 1.4

5.2 ± 2.1

3.0 ± 1.3

11.1 ± 3.8

1.5 ± 0.7

1.0 ± 0.3

0.6 (0.4,1.9)

 

P

 

0.332

0.946

0.075

0.144

0.347

0.931

0.174

0.308

< 0.001

0.246

0.565

C3

(−)

162

131.5 ± 18.7

37.9 (31.2,41.2)

91.9 ± 31.5

79.4 (62.6,99.0)

1.8 ± 1.5

5.4 ± 2.4

2.6 ± 1.1

10.1 ± 3.5

1.4 ± 0.8

1.0 ± 0.2

0.6 (0.3,1.6)

 

Mesangial-only

127

129.1 ± 17.2

37.7 (33.9,41.1)

94.4 ± 34.1

77.6 (56.4,99.1)

2.1 ± 2.7

5.1 ± 2.3

2.8 ± 1.1

10.5 ± 2.9

1.4 ± 0.7

1.0 ± 0.3a

0.5 (0.3,1.3)

 

Mesangial +GCLs

46

129.7 ± 20.7

35.5 (33.1,39.5)

89.5 ± 30.5

79.8 (60.3,104.4)

1.8 ± 1.6

5.0 ± 1.4

2.8 ± 1.0

10.5 ± 3.3

1.3 ± 0.7

1.0 ± 0.2

1.0 (0.4,1.5)

 

P

 

0.291

0.321

0.673

0.541

0.662

0.297

0.147

0.723

0.466

0.005

0.102

Fib

(−)

299

129.7 ± 18.3

37.6 (32.6,41.1)

92.3 ± 33.5

79.3 (59.4,100.8)

1.9 ± 2.0

5.3 ± 2.3

2.7 ± 1.1

10.2 ± 3.3

1.4 ± 0.7

1.0 ± 0.3

0.6 (0.3,1.6)

 

Mesangial-only

17

132.2 ± 17.9

37.0 (33.8,38.7)

87.6 ± 17.3

73.9 (63.4,89.2)

1.7 ± 1.0

4.4 ± 1.2

3.2 ± 0.9

11.4 ± 3.4

1.3 ± 0.7

0.9 ± 0.2

0.5 (0.3,1.4)

 

Mesangial +GCLs

19

139.5 ± 17.4

37.9 (34.4,41.1)

95.2 ± 23.7

70.6 (60.4,99.9)

2.9 ± 3.1

5.2 ± 1.3

2.9 ± 1.4

10.0 ± 2.7

1.1 ± 0.4

1.1 ± 0.2

0.7 (0.5,1.7)

 

P

 

0.168

0.772

0.747

0.819

0.363

0.388

0.126

0.337

0.453

0.079

0.461

C1q

(−)

303

130.0 ± 18.5

37.6 (33.6,41.1)

93.2 ± 31.5

78.0 (59.3,98.2)

1.8 ± 1.8

5.2 ± 2.2

2.7 ± 1.0

10.3 ± 3.2

1.4 ± 0.7

1.0 ± 0.3

0.6 (0.3,1.5)

 

Mesangial-only

19

134.7 ± 16.4

35.6 (31.2,39.2)

81.9 ± 31.4

85.4 (66.1,138.7)

3.3 ± 4.8

5.4 ± 1.8

2.8 ± 1.6

9.3 ± 3.7

1.5 ± 0.9

1.1 ± 0.5

1.2 (0.6,3.8) a

 

Mesangial +GCLs

14

131.3 ± 19.2

38.3 (32.5,41.1)

92.2 ± 46.1

91.1 (60.1,146.3)

2.0 ± 1.4

5.3 ± 2.4

3.0 ± 1.3

11.2 ± 4.0

1.3 ± 0.8

1.1 ± 0.2

1.1 (0.4,2.6)

 

P

 

0.586

0.400

0.269

0.185

0.159

0.755

0.820

0.317

0.708

0.391

0.010

  1. Abbreviations: eGFR estimated glomerular filtration rate, Scr serum creatinine, TG triglyceride, CHOL cholesterol, C3 complement 3, Fib Fibrinogen, IgG (−) without IgG deposits, IgM (−) without IgM deposits, C3(−) without C3 deposits, Fib (−) without Fib deposits, C1q (−) without C1q deposits, GCLs glomerular capillary loops
  2. * P compare between the IgA groups
  3. a P compare with (−) group
  4. b P compare with the Mesangial-only group
  5. Statistically significant at P < 0.05
  6. The patients with immune deposits in the GCLs group were excluded due to the small sample size