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Table 4 Comparison of laboratory data according to the location of immunofluorescence deposits at diagnosis

From: Immunofluorescence deposits in the mesangial area and glomerular capillary loops did not affect the prognosis of immunoglobulin a nephropathy except C1q:a single-center retrospective study

Parameter N Hemoglobin (g/L) Serum
albumin (g/L)
eGFR
(ml/min/1.73m2)
Scr
(μmol/L)
TG
(mmol/L)
CHOL (mmol/L) Serum
IgA (g/L)
Serum
IgG (g/L)
Serum
IgM (g/L)
Serum
C3 (g/L)
Proteinuria
(g/24 h)
IgA Mesangial-only 251 130.1 ± 18.1 37.7 (33.7,41.1) 92.4 ± 31.9 78.2 (59.2,78.2) 1.9 ± 2.1 5.1 ± 2.2 2.7 ± 1.1 10.4 ± 3.3 1.4 ± 0.7 1.0 ± 0.3 0.5 (0.3,1.5)
  Mesangial +GCLs 86 130.9 ± 19.2 36.7 (31.3,40.5) 92.3 ± 33.3 80.2 (62.1,103.0) 2.0 ± 1.9 5.5 ± 2.2 2.8 ± 1.1 9.8 ± 3.2* 1.3 ± 0.6 1.0 ± 0.2 1.1 (0.5,1.9) *
  P   0.925 0.276 0.754 0.454 0.607 0.077 0.896 0.048 0.266 0.125 < 0.001
IgG (−) 258 130.3 ± 18.6 37.6 (33.7,41.1) 91.3 ± 31.2 79.3 (60.3,102.8) 2.0 ± 2.3 5.3 ± 2.3 2.7 ± 1.1 10.2 ± 3.2 1.4 ± 0.7 1.0 ± 0.3 0.6 (0.3,1.6)
  Mesangial-only 32 132.4 ± 18.7 37.9 (34.1,40.6) 101.6 ± 34.5 73.0 (58.4,92.3) 1.4 ± 0.8 4.6 ± 2.0 2.9 ± 1.2 11.0 ± 3.2 1.5 ± 0.8 0.9 ± 0.3 0.4 (0.2,0.7)
  Mesangial +GCLs 33 128.5 ± 17.2 35.8 (28.8,41.3) 94.9 ± 37.6 70.6 (59.5,95.6) 1.7 ± 1.3 5.6 ± 2.0b 2.8 ± 1.2 9.9 ± 3.6 1.4 ± 0.7 1.0 ± 0.2 1.2 (0.4,3.1) b
  P   0.646 0.758 0.382 0.289 0.325 0.044 0.488 0.406 0.742 0.157 0.008
IgM (−) 199 129.0 ± 18.4 37.6 (33.7,41.1) 89.7 ± 32.0 80.5 (62.6,102.8) 1.7 ± 1.5 5.1 ± 2.1 2.6 ± 1.0 10.2 ± 3.2 1.2 ± 0.6 1.0 ± 0.2 0.6 (0.3,1.6)
  Mesangial-only 102 132.8 ± 17.6 36.4 (32.6,41.2) 97.9 ± 32.2 72.2 (58.3,95.4) 2.4 ± 3.0 5.4 ± 2.5 2.8 ± 1.1 10.2 ± 3.3 1.6 ± 0.8a 1.1 ± 0.3 0.6 (0.3,1.5)
  Mesangial +GCLs 35 130.8 ± 20.2 37.1 (33.7,40.6) 92.5 ± 32.3 74.3 (59.9,103.3) 1.8 ± 1.4 5.2 ± 2.1 3.0 ± 1.3 11.1 ± 3.8 1.5 ± 0.7 1.0 ± 0.3 0.6 (0.4,1.9)
  P   0.332 0.946 0.075 0.144 0.347 0.931 0.174 0.308 < 0.001 0.246 0.565
C3 (−) 162 131.5 ± 18.7 37.9 (31.2,41.2) 91.9 ± 31.5 79.4 (62.6,99.0) 1.8 ± 1.5 5.4 ± 2.4 2.6 ± 1.1 10.1 ± 3.5 1.4 ± 0.8 1.0 ± 0.2 0.6 (0.3,1.6)
  Mesangial-only 127 129.1 ± 17.2 37.7 (33.9,41.1) 94.4 ± 34.1 77.6 (56.4,99.1) 2.1 ± 2.7 5.1 ± 2.3 2.8 ± 1.1 10.5 ± 2.9 1.4 ± 0.7 1.0 ± 0.3a 0.5 (0.3,1.3)
  Mesangial +GCLs 46 129.7 ± 20.7 35.5 (33.1,39.5) 89.5 ± 30.5 79.8 (60.3,104.4) 1.8 ± 1.6 5.0 ± 1.4 2.8 ± 1.0 10.5 ± 3.3 1.3 ± 0.7 1.0 ± 0.2 1.0 (0.4,1.5)
  P   0.291 0.321 0.673 0.541 0.662 0.297 0.147 0.723 0.466 0.005 0.102
Fib (−) 299 129.7 ± 18.3 37.6 (32.6,41.1) 92.3 ± 33.5 79.3 (59.4,100.8) 1.9 ± 2.0 5.3 ± 2.3 2.7 ± 1.1 10.2 ± 3.3 1.4 ± 0.7 1.0 ± 0.3 0.6 (0.3,1.6)
  Mesangial-only 17 132.2 ± 17.9 37.0 (33.8,38.7) 87.6 ± 17.3 73.9 (63.4,89.2) 1.7 ± 1.0 4.4 ± 1.2 3.2 ± 0.9 11.4 ± 3.4 1.3 ± 0.7 0.9 ± 0.2 0.5 (0.3,1.4)
  Mesangial +GCLs 19 139.5 ± 17.4 37.9 (34.4,41.1) 95.2 ± 23.7 70.6 (60.4,99.9) 2.9 ± 3.1 5.2 ± 1.3 2.9 ± 1.4 10.0 ± 2.7 1.1 ± 0.4 1.1 ± 0.2 0.7 (0.5,1.7)
  P   0.168 0.772 0.747 0.819 0.363 0.388 0.126 0.337 0.453 0.079 0.461
C1q (−) 303 130.0 ± 18.5 37.6 (33.6,41.1) 93.2 ± 31.5 78.0 (59.3,98.2) 1.8 ± 1.8 5.2 ± 2.2 2.7 ± 1.0 10.3 ± 3.2 1.4 ± 0.7 1.0 ± 0.3 0.6 (0.3,1.5)
  Mesangial-only 19 134.7 ± 16.4 35.6 (31.2,39.2) 81.9 ± 31.4 85.4 (66.1,138.7) 3.3 ± 4.8 5.4 ± 1.8 2.8 ± 1.6 9.3 ± 3.7 1.5 ± 0.9 1.1 ± 0.5 1.2 (0.6,3.8) a
  Mesangial +GCLs 14 131.3 ± 19.2 38.3 (32.5,41.1) 92.2 ± 46.1 91.1 (60.1,146.3) 2.0 ± 1.4 5.3 ± 2.4 3.0 ± 1.3 11.2 ± 4.0 1.3 ± 0.8 1.1 ± 0.2 1.1 (0.4,2.6)
  P   0.586 0.400 0.269 0.185 0.159 0.755 0.820 0.317 0.708 0.391 0.010
  1. Abbreviations: eGFR estimated glomerular filtration rate, Scr serum creatinine, TG triglyceride, CHOL cholesterol, C3 complement 3, Fib Fibrinogen, IgG (−) without IgG deposits, IgM (−) without IgM deposits, C3(−) without C3 deposits, Fib (−) without Fib deposits, C1q (−) without C1q deposits, GCLs glomerular capillary loops
  2. * P compare between the IgA groups
  3. a P compare with (−) group
  4. b P compare with the Mesangial-only group
  5. Statistically significant at P < 0.05
  6. The patients with immune deposits in the GCLs group were excluded due to the small sample size