Immunofluorescence deposits in the mesangial area and glomerular capillary loops did not affect the prognosis of immunoglobulin a nephropathy except C1q:a single-center retrospective study

Table 6 Comparison of the Oxford classification according to the location of immunofluorescence deposits at diagnosis

Parameters		N	M1 (%)	E1 (%)	S1 (%)	T (1 + 2) (%)	C (1 + 2) (%)
IgA	Mesangial-only	251	4.8	7.6	69.7	73.3	35.9
	Mesangial +GCLs	86	5.6	7.0	77.9	73.9	43.0
	P		0.244	0.856	0.145	0.679	0.237
IgG	(−)	258	4.7	7.8	71.7	76.4	36.0
	Mesangial-only	32	6.3	9.4	68.8	56.3 ^a	43.8
	Mesangial +GCLs	33	15.2 ^a	6.1	78.8	69.7	42.4
	P		0.037	0.882	0.627	0.044	0.575
IgM	(−)	199	6.0	9.5	69.8	77.9	42.2
	Mesangial-only	102	3.9	5.9	70.6	66.7	28.4
	Mesangial +GCLs	35	8.6	0.0	85.7	71.4	37.1
	P		0.553	0.108	0.150	0.105	0.065
C3	(−)	162	4.9	8.6	69.8	74.7	34.6
	Mesangial-only	127	4.7	6.3	70.9	74.8	40.2
	Mesangial +GCLs	46	10.9	6.5	80.4	69.6	41.3
	P		0.259	0.728	0.355	0.758	0.533
Fib	(−)	299	6.4	8.0	70.9	75.3	36.8
	Mesangial-only	17	0.0	0.0	82.4	64.7	47.1
	Mesangial +GCLs	19	0.0	5.3	73.7	57.9	36.8
	P		0.297	0.440	0.583	0.171	0.695
C1q	(−)	303	5.3	7.6	71.0	74.3	38.3
	Mesangial-only	19	5.3	10.5	84.2	68.4	36.8
	Mesangial +GCLs	14	7.1	0.0	71.4	71.4	21.4
	P		0.955	0.497	0.461	0.836	0.444

Abbreviations: Fib Fibrinogen, IgG (−) without IgG deposits, IgM (−) without IgM deposits, C3(−) without C3 deposits, Fib (−) without Fib deposits, C1q (−) without C1q deposits, GCLs glomerular capillary loops, M mesangial hypercellularity, E endocapillary hypercellularity, S segmental glomerulosclerosis, T tubular atrophy/interstitial fibrosis, C Cellular or fibrocellular crescents
* P compare between the IgA groups
^a P compare with (−) group
^b P compare with the Mesangial-only group
Statistically significant at P < 0.05
The patients with immune deposits in the GCLs group were excluded due to the small sample size

ISSN: 1471-2369