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Table 7 The association of immunofluorescence deposits

From: Immunofluorescence deposits in the mesangial area and glomerular capillary loops did not affect the prognosis of immunoglobulin a nephropathy except C1q:a single-center retrospective study

Parameter

N

IgA (n, %)

  

IgG (n, %)

IgM (n, %)

C3 (n, %)

  

Fib (n, %)

C1q (n, %)

1+

2+

≥3+

(+)

(+)

(−)

<2+

≥ 2+

(+)

(+)

IgA

Mesangial-only

251

51 (20.3)

78 (31.1)

122 (48.6)

46 (18.3)

100 (39.8)

115 (45.8)

42 (16.7)

94 (37.5)

23 (9.2)

19 (7.6)

 

Mesangial +GCLs

86

18 (20.9)

25 (29.1)

43 (50.0)

33 (38.4) *

38 (44.2)

47 (54.7)

12 (14.0)

27 (31.4)

15 (17.4) *

15 (17.4) *

 

P

 

0.941

  

< 0.001

0.479

0.367

  

0.036

0.009

IgG

(−)

258

54 (20.9)

83 (32.2)

121 (46.9)

 

104 (40.3)

122 (47.3)

43 (16.7)

93 (36.0)

23 (8.9)

20 (7.8)

 

Mesangial-only

32

1 (3.1) a

9 (28.1)

22 (68.8)

 

17 (53.1)

12 (37.5)

3 (9.4)

17 (53.1)

6 (18.8)

4 (12.5)

 

Mesangial +GCLs

33

7 (21.2)

7 (21.2)

19 (57.6)

 

14 (42.4)

17 (51.5)

6 (18.2)

10 (30.3)

8 (24.2) a

9 (27.3) a

 

P

 

0.024

   

0.383

0.232

  

0.013

0.002

IgM

(−)

199

50 (25.1)

64 (32.2)

85 (42.7)

45 (22.6)

 

105 (52.8)

33 (16.6)

61 (30.7)

12 (6.0)

11 (5.5)

 

Mesangial-only

102

15 (14.7) a

27 (26.5)

60 (58.8)

20 (19.6)

 

44 (43.1)

14 (13.7)

44 (43.1)

17 (16.7) a

12 (11.8)

 

Mesangial +GCLs

35

3 (8.6)

12 (34.3)

20 (57.1)

13 (37.1)

 

13 (37.1)

6 (17.1)

16 (45.7)

9 (25.7) a

11 (31.4) ab

 

P

 

0.007

  

0.101

 

0.053

  

< 0.001

< 0.001

C3

(−)

162

58 (35.8)

55 (34.0)

49 (30.2)

40 (24.7)

57 (35.2)

   

15 (9.3)

15 (9.3)

 

Mesangial-only

127

10 (7.9) a

35 (27.6)

82 (64.6)

18 (14.2)

54 (42.5)

   

9 (7.1)

6 (4.7)

 

Mesangial +GCLs

46

0 (0.0) a

13 (28.3)

33 (71.7)

19 (41.3) b

26 (56.5) a

   

14 (30.4) ab

13 (28.3) ab

 

P

 

< 0.001

  

0.001

0.031

   

< 0.001

< 0.001

Fib

(−)

299

67 (22.4)

96 (32.1)

136 (45.5)

64 (21.4)

112 (37.5)

147 (49.2)

48 (16.1)

104 (34.8)

 

24 (8.0)

 

Mesangial-only

17

2 (11.8)

3 (17.6)

12 (70.6)

5 (29.4)

11 (64.7)

10 (58.8)

2 (11.8)

5 (29.4)

 

2 (11.8)

 

Mesangial +GCLs

19

0 (0.0) a

4 (21.1)

15 (78.9)

9 (47.4) a

14 (73.7) a

5 (26.3)

4 (21.1)

10 (52.6)

 

8 (42.1) ab

 

P

 

0.002

  

0.029

0.001

0.117

   

< 0.001

C1q

(−)

303

66 (21.8)

94 (31.0)

143 (47.2)

65 (21.5)

115 (38.0)

147 (48.5)

47 (15.5)

109 (36.0)

28 (9.2)

 
 

Mesangial-only

19

3 (15.8)

6 (31.6)

10 (52.6)

5 (26.3)

12 (63.2)

11 (57.9)

2 (10.5)

6 (31.6)

5 (26.3)

 
 

Mesangial +GCLs

14

0 (0.0) a

3 (21.4)

11 (78.6)

8 (57.1) a

11 (78.6) a

4 (28.6)

5 (35.7)

5 (35.7)

5 (35.7) a

 
 

P

 

0.041

  

0.008

0.001

0.530

  

0.001

 
  1. Abbreviations: Fib Fibrinogen, IgG (−) without IgG deposits, IgM (−) without IgM deposits, C3(−) without C3 deposits, Fib (−) without Fib deposits, C1q (−) without C1q deposits, GCLs glomerular capillary loops
  2. * P compare between the IgA groups
  3. a P compare with (−) group
  4. b P compare with the Mesangial-only group
  5. Statistically significant at P < 0.05
  6. The patients with immune deposits in the GCLs group were excluded due to small sample size
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BMC Nephrology

ISSN: 1471-2369

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