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Table 7 The association of immunofluorescence deposits

From: Immunofluorescence deposits in the mesangial area and glomerular capillary loops did not affect the prognosis of immunoglobulin a nephropathy except C1q:a single-center retrospective study

Parameter N IgA (n, %)    IgG (n, %) IgM (n, %) C3 (n, %)    Fib (n, %) C1q (n, %)
1+ 2+ ≥3+ (+) (+) (−) <2+ ≥ 2+ (+) (+)
IgA Mesangial-only 251 51 (20.3) 78 (31.1) 122 (48.6) 46 (18.3) 100 (39.8) 115 (45.8) 42 (16.7) 94 (37.5) 23 (9.2) 19 (7.6)
  Mesangial +GCLs 86 18 (20.9) 25 (29.1) 43 (50.0) 33 (38.4) * 38 (44.2) 47 (54.7) 12 (14.0) 27 (31.4) 15 (17.4) * 15 (17.4) *
  P   0.941    < 0.001 0.479 0.367    0.036 0.009
IgG (−) 258 54 (20.9) 83 (32.2) 121 (46.9)   104 (40.3) 122 (47.3) 43 (16.7) 93 (36.0) 23 (8.9) 20 (7.8)
  Mesangial-only 32 1 (3.1) a 9 (28.1) 22 (68.8)   17 (53.1) 12 (37.5) 3 (9.4) 17 (53.1) 6 (18.8) 4 (12.5)
  Mesangial +GCLs 33 7 (21.2) 7 (21.2) 19 (57.6)   14 (42.4) 17 (51.5) 6 (18.2) 10 (30.3) 8 (24.2) a 9 (27.3) a
  P   0.024     0.383 0.232    0.013 0.002
IgM (−) 199 50 (25.1) 64 (32.2) 85 (42.7) 45 (22.6)   105 (52.8) 33 (16.6) 61 (30.7) 12 (6.0) 11 (5.5)
  Mesangial-only 102 15 (14.7) a 27 (26.5) 60 (58.8) 20 (19.6)   44 (43.1) 14 (13.7) 44 (43.1) 17 (16.7) a 12 (11.8)
  Mesangial +GCLs 35 3 (8.6) 12 (34.3) 20 (57.1) 13 (37.1)   13 (37.1) 6 (17.1) 16 (45.7) 9 (25.7) a 11 (31.4) ab
  P   0.007    0.101   0.053    < 0.001 < 0.001
C3 (−) 162 58 (35.8) 55 (34.0) 49 (30.2) 40 (24.7) 57 (35.2)     15 (9.3) 15 (9.3)
  Mesangial-only 127 10 (7.9) a 35 (27.6) 82 (64.6) 18 (14.2) 54 (42.5)     9 (7.1) 6 (4.7)
  Mesangial +GCLs 46 0 (0.0) a 13 (28.3) 33 (71.7) 19 (41.3) b 26 (56.5) a     14 (30.4) ab 13 (28.3) ab
  P   < 0.001    0.001 0.031     < 0.001 < 0.001
Fib (−) 299 67 (22.4) 96 (32.1) 136 (45.5) 64 (21.4) 112 (37.5) 147 (49.2) 48 (16.1) 104 (34.8)   24 (8.0)
  Mesangial-only 17 2 (11.8) 3 (17.6) 12 (70.6) 5 (29.4) 11 (64.7) 10 (58.8) 2 (11.8) 5 (29.4)   2 (11.8)
  Mesangial +GCLs 19 0 (0.0) a 4 (21.1) 15 (78.9) 9 (47.4) a 14 (73.7) a 5 (26.3) 4 (21.1) 10 (52.6)   8 (42.1) ab
  P   0.002    0.029 0.001 0.117     < 0.001
C1q (−) 303 66 (21.8) 94 (31.0) 143 (47.2) 65 (21.5) 115 (38.0) 147 (48.5) 47 (15.5) 109 (36.0) 28 (9.2)  
  Mesangial-only 19 3 (15.8) 6 (31.6) 10 (52.6) 5 (26.3) 12 (63.2) 11 (57.9) 2 (10.5) 6 (31.6) 5 (26.3)  
  Mesangial +GCLs 14 0 (0.0) a 3 (21.4) 11 (78.6) 8 (57.1) a 11 (78.6) a 4 (28.6) 5 (35.7) 5 (35.7) 5 (35.7) a  
  P   0.041    0.008 0.001 0.530    0.001  
  1. Abbreviations: Fib Fibrinogen, IgG (−) without IgG deposits, IgM (−) without IgM deposits, C3(−) without C3 deposits, Fib (−) without Fib deposits, C1q (−) without C1q deposits, GCLs glomerular capillary loops
  2. * P compare between the IgA groups
  3. a P compare with (−) group
  4. b P compare with the Mesangial-only group
  5. Statistically significant at P < 0.05
  6. The patients with immune deposits in the GCLs group were excluded due to small sample size