Table 1 Baseline characteristics stratified with RI at 1 month and 3 months after transplantation
Overall | RI < 0.70 1 month | RI < 0.70 1 month | RI ≥ 0.70 1 month | RI ≥ 0.70 1 month | p | |
|---|---|---|---|---|---|---|
RI < 0.70 3 months | RI ≥ 0.70 3 months | RI < 0.70 3 months | RI ≥ 0.70 3 months | |||
Total patients | 1685 | 661 | 160 | 216 | 648 | |
Donor characteristics | ||||||
Cardiovascular death (%) | 924 (61.4) | 296 (52.4) | 103 (70.5) | 110 (58.8) | 415 (68.4) | < 0.001 |
Deceased donor (%) | 1590 (94.4) | 606 (91.7) | 150 (93.8) | 203 (94.0) | 631 (97.4) | < 0.001 |
Donor age (years) | 50.95 (17.54) | 42.12 (15.65) | 51.86 (16.09) | 50.99 (15.36) | 59.72 (15.87) | < 0.001 |
Donor with diabetes (%) | 95 (5.7) | 14 (2.1) | 3 (1.9) | 13 (6.1) | 65 (10.1) | < 0.001 |
Donor gender (% Male) | 1002 (59.5) | 407 (61.6) | 90 (56.2) | 129 (59.7) | 376 (58.0) | 0.481 |
Cold Ischemia (hours) | 17.81 (7.95) | 17.36 (8.22) | 17.41 (7.49) | 17.59 (8.23) | 18.43 (7.66) | 0.085 |
Recipient characteristics at time of transplantation | ||||||
Diabetes (%) | 263 (15.9) | 19 (2.9) | 18 (11.2) | 31 (14.9) | 195 (30.5) | < 0.001 |
NODAT (%) | 214 (12.9) | 76 (11.7) | 24 (15.1) | 23 (11.1) | 91 (14.2) | 0.379 |
Hemodialysis time (years) | 2.95 (3.34) | 3.00 (3.83) | 2.79 (2.95) | 2.99 (3.33) | 2.91 (2.90) | 0.902 |
Age (years) | 51.15 (14.78) | 41.33 (12.69) | 51.00 (12.45) | 50.95 (12.88) | 61.28 (10.47) | < 0.001 |
Year of transplantation (%) | < 0.001 | |||||
1985–1989 | 44 (2.6) | 23 (3.5) | 3 (1.9) | 6 (2.8) | 12 (1.9) | |
1990–1999 | 270 (16.0) | 120 (18.2) | 28 (17.5) | 39 (18.1) | 83 (12.8) | |
2000–2009 | 584 (34.7) | 257 (38.9) | 69 (43.1) | 70 (32.4) | 188 (29.0) | |
2010–2017 | 787 (46.7) | 261 (39.5) | 60 (37.5) | 101 (46.8) | 365 (56.3) | |
Gender (% Male) | 1074 (63.7) | 440 (66.6) | 99 (61.9) | 149 (69.0) | 386 (59.6) | 0.019 |
BMI (kg/m2) | 25.31 (4.88) | 24.14 (4.59) | 24.86 (4.95) | 25.18 (4.67) | 26.67 (4.91) | < 0.001 |
Graft rank (%) | 0.772 | |||||
1 | 1433 (85.0) | 551 (83.4) | 139 (86.9) | 187 (86.6) | 556 (85.8) | |
2 | 213 (12.6) | 95 (14.4) | 19 (11.9) | 22 (10.2) | 77 (11.9) | |
3 | 37 (2.2) | 14 (2.1) | 2 (1.2) | 7 (3.2) | 14 (2.2) | |
4 | 2 (0.1) | 1 (0.2) | 0 (0.0) | 0 (0.0) | 1 (0.2) | |
Perfusion machine (%) | 242 (14.4) | 38 (5.7) | 12 (7.5) | 23 (10.6) | 169 (26.1) | < 0.001 |
Double transplantation (%) | 26 (1.5) | 2 (0.3) | 3 (1.9) | 3 (1.4) | 18 (2.8) | 0.004 |
DGF (%) | 320 (19.0) | 88 (13.3) | 26 (16.2) | 45 (20.8) | 161 (24.8) | < 0.001 |
Thymoglobulin (%) | 915 (54.4) | 373 (56.6) | 89 (55.6) | 115 (53.2) | 338 (52.2) | 0.422 |
IL2-R antibodies (%) | 744 (44.3) | 271 (41.2) | 68 (42.8) | 99 (45.8) | 306 (47.4) | 0.144 |
Recipients characteristics at 3 months | ||||||
SBP (mmHg) | 138.54 (15.90) | 135.58 (14.86) | 135.69 (15.79) | 136.80 (14.52) | 143.10 (16.45) | < 0.001 |
DBP (mmHg) | 78.79 (10.57) | 81.61 (10.03) | 78.81 (9.24) | 79.96 (9.35) | 75.31 (10.88) | < 0.001 |
PP (mmHg) | 59.75 (15.19) | 53.96 (12.32) | 56.88 (13.79) | 56.84 (11.93) | 67.80 (15.90) | < 0.001 |
eGFR (ml/min/1.73 m2) | 51.39 (19.09) | 56.89 (21.13) | 49.71 (16.66) | 51.10 (16.56) | 45.94 (16.36) | < 0.001 |
Proteinuria (g/day) | 0.80 (8.39) | 1.23 (13.41) | 0.43 (0.41) | 0.55 (0.87) | 0.55 (0.70) | 0.648 |
Tacrolimus (%) | 823 (55.9) | 315 (53.0) | 68 (47.6) | 109 (57.1) | 331 (60.7) | 0.010 |
Ciclosporine (%) | 586 (39.8) | 267 (44.9) | 66 (46.2) | 74 (38.7) | 179 (32.8) | < 0.001 |
Steroids (%) | 1408 (95.7) | 571 (96.1) | 135 (95.1) | 180 (94.2) | 522 (95.8) | 0.711 |
MMF (%) | 1193 (81.0) | 480 (80.8) | 116 (81.1) | 149 (78.0) | 448 (82.2) | 0.651 |
Azathioprine (%) | 234 (15.9) | 99 (16.7) | 23 (16.1) | 34 (17.9) | 78 (14.3) | 0.602 |
m-TOR inhibitors (%) | 97 (6.6) | 19 (3.2) | 13 (9.1) | 12 (6.2) | 53 (9.7) | < 0.001 |
Resistive index M1 | 0.70 (0.08) | 0.63 (0.05) | 0.65 (0.04) | 0.73 (0.03) | 0.77 (0.06) | < 0.001 |
Resistive index M3 | 0.69 (0.08) | 0.62 (0.05) | 0.73 (0.03) | 0.65 (0.04) | 0.77 (0.05) | < 0.001 |
Resistive index M1 > 0.70 | 864 (51.3) | 0 (0.0) | 0 (0.0) | 216 (100.0) | 648 (100.0) | < 0.001 |
Resistive index M3 > 0.70 | 808 (48.0) | 0 (0.0) | 160 (100.0) | 0 (0.0) | 648 (100.0) | < 0.001 |