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Table 1 Main characteristics of included studies

From: Effect of omega-3 fatty acids supplementation on cardio-metabolic and oxidative stress parameters in patients with chronic kidney disease: a systematic review and meta-analysis

Study (year)

Country

Subjects

Sample size

N-3 fatty acids Dosage

(per day)

Duration

(week)

Gender

(M/F)

Age

Main outcome

N-3 Dose

(mg)

EPA (mg)

DHA (mg)

ALA (mg)

Placebo

Mean ± SD

Intervention

Mean ± SD

Ando

et al [23]

(1999)

Japan

HD a

38

1800

1638

–

–

12

33/5

51 ± 13

54 ± 11

↓TC c, ↓TG d,

↔HDL e

Ateya

et al [24]

(2017)

Egypt

HD

49

1000

500

250

–

16

27/22

14.6 ± 2.7

14.7 ± 2.7

↔TC, ↓TG,

↔HDL,

↔LDL f,

↔MDA g

,↑GPx h,↑SOD i

Bouzidi

et al [25]

(2010)

Algeria

CRF b

40

2100

693

252

–

12

22/18

61 ± 14

61 ± 14

↓TG,

↑GPx,

↑SOD,

↔HDL, ↔LDL,

↔TC

Alexopoulos

et al [26]

(2004)

Greece

IgA Nephropathy

28

3000

850

580

 

192

22/6

39 ± 10

41 ± 12

↔TG

Gharekhani

et al [27]

(2016)

Iran

HD

45

1800

1080

720

–

16

25/20

57.2 ± 15.19

56.8 ± 13.09

↔LDL,↓TG,↓TC,↓HDL

Jabbari

et al [28]

(2016)

Iran

HD

117

3000

 

–

 

12

75/25

61.05 ± 17.42

64.58 ± 12.61

↔TC, ↔TG, ↔LDL

, ↑HDL

Khajehdehi [29]

(2000)

Iran

HD

30

1500

 

–

 

8

15/15

32.4 ± 9.2

32.7 ± 10.7

↔TC,

↓ TG, ↓LDL, ↑HDL

Moeinzadeh [30]

et al (2011)

Iran

HD

52

3000

540

360

–

24

36/16

58.34 ± 14.36

57.76 ± 15.56

↑HDL, ↔LDL, ↔TC,

↔TG

Naini et al [31]

(2015)

Iran

PDl

90

3000

540

360

–

8

51/39

59.36 ± 13.4

57.7 ± 16.3

↓DBP j, ↓SBP k,

↔HDL

,↔LDL,

↔TC,

↔TG

Pettersson [32]

et al

(1994)

Sweden

IgA Nephropathy

32

6000

2800

1530

–

24

25/7

42

39

↔HDL,

↔TC

,↓TG,

↔LDL,

↔SBP,

↔DBP

Schmitz [33]

et al

(2002)

USA

HD

24

4000

1760

960

–

48

11/13

54 ± 3

52 ± 6

↓TG

Tayyebi-Khosroshahi et al [34]

(2013)

Iran

HD

88

3000

540

360

–

8

63/25

48.60

51.50

↔HDL, ↔LDL, ↔TC, ↔TG

Tayyebi-Khosroshahi et al [35]

(2010)

Iran

HD

75

3000

540

360

–

8

49/26

49.3 ± 1.8

48.8 ± 2.7

↑GPX, ↓MDA, ↑SOD,

  1. a Hemodialysis, bChronic Renal Failure, c Total cholesterol, d Triglyceride, e High-density lipoprotein, f low-density lipoprotein, g Malondialdehyde, h Glutathione peroxidase, i Superoxide dismutase, j diastolic blood pressure, k Systolic blood pressure, l peritoneal dialysis