Fig. 3

Photomicrograph of the renal histology in different groups (trichrome masson stain×400). No histopathological changes were shown in the control (a), sham (b), and L-Ca 200 (c) groups. In the MSG group (d), an increment in local inflammation, edema, interstitial hemorrhage, and Hyaline casts (thin arrow) was observed multifocally from the cortex to the inner medulla along nephrons. Some of these hyaline casts contained red blood cells, and red blood cell casts were also observed (pick arrow). Small, focal hemorrhage was scattered in the interstitium in the cortex. On the other hand, the destruction and deformation of the proximal and distal convoluted tubules were observed in some places in the MSG group. The MSG + L-ca 100 group (e) showed no significant changes compared to the MSG group, while the MSG + L-ca 200 group (f) showed significant amelioration in the MSG-induced structure damages such as inflammation, edema, interstitial hemorrhage, and deformation of proximal and distal convoluted tubules in renal tissue. PCT: proximal convoluted tubule; DCT: Distal convoluted tubule. The thick arrow indicates the glomeruli of the kidney tissue