Fig. 1
From: Anti-fibrotic potential of erythropoietin signaling on bone marrow derived fibrotic cell
The mRNA expression levels of COL1 and EPO receptors were affected by TGF-β stimulation and EPO treatment in fibrocyte. Bone marrow derived fibrotic cells were isolated from PBMC of healthy control (a). TGF-β stimulation increased the expression of COL1 mRNA. EPO signal reduced the expression of COL1 mRNA in dose dependent manner (b). TGF-β stimulation induced the expression of EPOR (c), however it reduced the expression of βCR (d) in bone marrow derived fibrotic cells. EPO signaling did not change the expression levels of these receptors. Figures are representative of four independent experiments