Excretion of urine extracellular vesicles bearing markers of activated immune cells and calcium/phosphorus physiology differ between calcium kidney stone formers and non-stone formers

Table 2 Urinary excretion of EVs carrying biomarkers of immune/ inflammatory cells in CSFs and NSFs

Urinary EVs/ mg creatinine	Marker	NSF (n = 21)	High RP CSF (n = 8)		CSF (High + Low RP) (n = 24)
Total leukocyte	CD45	10.5 (10.2, 11.9)	10.1 ^a (9.4, 10.3)	10.1 ^b (9.5, 10.7)	10.1 ^c (9.5, 10.3)
Neutrophil	CD15	11.7 (10.8, 12.6)	10.8 (10.0, 11.7)	10.8 (10.2, 11.5)	10.8 ^c (10.2, 11.5)
B-lymphocyte	CD19	11.0 (10.0, 12.3)	10.0 (9.7, 11.2)	10.0 (9.7, 11.2)	10.0 (9.7, 11.2)
T-lymphocyte	CD3	10.5 (10.1, 11.4)	10.3 (9.8, 10.4)	10.2 (9.7, 10.5)	10.2 (9.8, 10.5)
Monocyte	CD14	11.4 (10.1, 12.3)	10.4 (9.7, 11.2)	10.2 (9.5, 11.4)	10.3 (9.5, 11.2)
Macrophage	CD68	10.9 (10.4, 12.2)	10.0 ^a (9.5, 10.7)	10.4 (10.1, 10.9)	10.3 ^c (9.8, 10.8)
Plasma cell	CD138 + CD319	8.9 (7.8, 10.6)	8.8 (8.3, 9.4)	8.4 (7.5, 9.5)	8.7 (7.7, 9.5)

Data are presented as median (25th and 75th percentile) of natural log of EVs/mg creatinine. P values in bold denote significance at < 0.05 level
^aSignificant difference between high RP-CSF and NSFs
^bSignificant difference between low RP-CSF and NSFs
^cSignificant difference between CSFs and NSFs

ISSN: 1471-2369