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Table 3 Urinary excretion of EVs carrying biomarkers of calcium and phosphorus physiology in CSFs and NSFs

From: Excretion of urine extracellular vesicles bearing markers of activated immune cells and calcium/phosphorus physiology differ between calcium kidney stone formers and non-stone formers

Urinary EVs/ mg creatinine

Marker

NSF

(n = 21)

High RP CSF (n = 8)

Low RP CSF (n = 16)

CSF

(High + Low RP) (n = 24)

Exosome generation

HIP1

11.7

(10.5, 12.7)

10.6

(10.2, 12.1)

10.8

(10.5, 11.4)

10.8

(10.3, 11.5)

Microvesicles generation

ANO4

12.0

(11.2, 13.0)

11.2

(10.2, 12.6)

11.3

(10.6, 12.3)

11.3 c

(10.5, 12.3)

Calcium/phosphorus regulators

FGF23

11.5

(10.0, 12.0)

9.8 a

(9.4, 11.2)

10.4

(9.8, 11.0)

10.0 c

(9.7, 11.0)

Calcium/phosphorus regulators

Klotho

13.6

(13.0, 14.7)

12.9

(12.4, 14.3)

12.5 b

(11.6, 13.0)

12.5 c

(11.7, 13.5)

Phosphate transporter 1

PiT1

12.1

(10.8, 13.0)

10.5 a

(10.2, 11.7)

10.6 b

(10.0, 11.6)

10.6 c

(10.1, 11.6)

Phosphate transporter 2

PiT2

12.8

(11.6, 14.7)

11.8

(11.1, 13.8)

11.6

(10.6, 13.0)

11.7 c

(10.9, 13.0)

  1. Data are presented as median (25th and 75th percentile) of natural log of EVs/mg creatinine. P values in bold denote significance at < 0.05 level
  2. aSignificant difference between high RP-CSF and NSFs
  3. bSignificant difference between low RP-CSF and NSFs
  4. cSignificant difference between CSFs and NSFs
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BMC Nephrology

ISSN: 1471-2369

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