Table 6 Correlation between specific populations of urinary extracellular vesicles (EVs), clinical stone events, and papillary tip histology in calcium kidney stone formers
Urinary EV population | Spearman’ correlation (ρ) | P-value |
|---|---|---|
Clinical Stones | ||
Total Stone Events | ||
HIP1 positive EVs | -0.47 | < 0.05 |
ANO4 positive EVs | -0.45 | < 0.05 |
Stones on imagining at the time of surgery | ||
HIP1 positive EVs | -0.37 | 0.06 |
Papillary Biopsy Findings | ||
Intraluminal crystals | ||
CD19 positive EVs | 0.59 | < 0.05 |
Punctate basement membrane crystals | ||
HIP1 positive EVs | -0.44 | < 0.05 |
ANO4 positive EVs | -0.57 | < 0.05 |
Klotho positive EVs | -0.55 | < 0.01 |
PiT1 positive EVs | -0.52 | < 0.01 |
PiT2 positive EVs | -0.45 | < 0.05 |
Dense basement membrane staining | ||
ANO4 positive EVs | -0.41 | 0.09 |
Interstitial inflammation | ||
CD19 positive EVs | 0.56 | < 0.05 |