Von Willebrand factor, ADAMTS13 and mortality in dialysis patients

BMC Nephrology

Table 2 Von Willebrand factor quartiles and mortality

	Total N=956	Mean level (ug/mL)	Mortality rate per 1000 patient years	Crude HR (95% CI)		Adjusted^a HR (95% CI)
All-cause mortality
Quartile 1	239	9.4	99	reference		reference
Quartile 2	239	15.4	129	1.3	(0.9-1.9)	1.2	(0.8-1.7)
Quartile 3	239	21.0	172	1.7	(1.2-2.5)	1.5	(1.1-2.2)
Quartile 4	239	36.2	209	2.1	(1.5-3.0)	1.8	(1.2-2.6)
*Quartile 4 versus Quartile 1-3*				*1.6*	*(1.2-2.0)*	*1.4*	*(1.1-1.8)*
Cardiovascular mortality
Quartile 1	239	9.4	51	reference		reference
Quartile 2	239	15.4	73	1.4	(0.8-2.3)	1.3	(0.8-2.1)
Quartile 3	239	21.0	82	1.6	(1.0-2.6)	1.4	(0.9-2.4)
Quartile 4	239	36.2	102	2.0	(1.2-3.3)	1.7	(1.0-2.8)
*Quartile 4 versus Quartile 1-3*				*1.5*	*(1.1-2.1)*	*1.3*	*(0.9-1.9)*
Non-cardiovascular mortality
Quartile 1	239	9.4	47	reference		reference
Quartile 2	239	15.4	56	1.2	(0.7-2.1)	1.1	(0.6-1.9)
Quartile 3	239	21.0	90	1.9	(1.2-3.2)	1.6	(1.0-2.8)
Quartile 4	239	36.2	107	2.3	(1.4-3.7)	1.9	(1.1-3.3)
*Quartile 4 versus Quartile 1-3*				*1.7*	*(1.2-2.4)*	*1.5*	*(1.0-2.2)*

^aAdjusted for age, sex, body mass index, cardiovascular disease, dialysis modality, smoking, primary kidney disease, use of antithrombotic medication, systolic blood pressure, albumin, C-reactive protein and residual GFR

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