Von Willebrand factor, ADAMTS13 and mortality in dialysis patients

BMC Nephrology

Table 3 ADAMTS13 quartiles and mortality

	Total N=956	Mean level (activity %)	Mortality rate per 1000 patient years	Crude HR (95% CI)		Adjusted^a HR (95% CI)
All-cause mortality
Quartile 1	239	16.7	181	1.3	(1.0-1.8)	1.2	(0.9-1.7)
Quartile 2	239	33.0	156	1.1	(0.8-1.6)	0.9	(0.7-1.3)
Quartile 3	239	45.7	132	1.0	(0.7-1.4)	0.9	(0.6-1.2)
Quartile 4	239	68.1	136	reference		reference
*Quartile 1 versus Quartile 2-4*				*1.3*	*(1.1-1.7)*	*1.3*	*(1.0-1.7)*
Cardiovascular mortality
Quartile 1	239	16.7	88	1.2	(0.8-1.8)	1.1	(0.7-1.8)
Quartile 2	239	33.0	80	1.1	(0.7-1.7)	0.9	(0.6-1.4)
Quartile 3	239	45.7	63	0.8	(0.5-1.4)	0.8	(0.5-1.3)
Quartile 4	239	68.1	75	reference		reference
*Quartile 1 versus Quartile 2-4*				*1.2*	*(0.9-1.6)*	*1.2*	*(0.9-1.8)*
Non-cardiovascular mortality
Quartile 1	239	16.7	92	1.5	(1.0-2.4)	1.3	(0.8-2.2)
Quartile 2	239	33.0	76	1.3	(0.8-2.0)	1.0	(0.6-1.6)
Quartile 3	239	45.7	69	1.1	(0.7-1.9)	1.0	(0.6-1.6)
Quartile 4	239	68.1	61	reference		reference
*Quartile 1 versus Quartile 2-4*				*1.4*	*(1.0-1.9)*	*1.4*	*(1.0-2.0)*

^aAdjusted for age, sex, body mass index, cardiovascular disease, smoking, dialysis modality, primary kidney disease, use of antithrombotic medication, systolic blood pressure, albumin, C-reactive protein and residual GFR

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