Positive renal familial history in IgA nephropathy is associated with worse renal outcomes: a single-center longitudinal study

Table 3 Multivariable Cox proportional hazards analysis for IgAN patients

Factors	Odds ratio	95% confidence Interval		P value
*Clinical background at Renal Biopsy*
History of Hypertension (presence to absence)	1.39	0.68	2.85	0.37
Mean arterial pressure (1 mmHg increase)	1	0.98	1.02	0.76
Age at renal biopsy (1 increase)	1.01	0.98	1.03	0.57
eGFR (ml/min/1.73m²)	0.97	0.96	0.99	< 0.01
Urinary protein (g/day) by 1 increase	1.17	1.04	1.31	0.01
Familial History (Positive or Negative)	2.31	1.1	4.85	0.03
Renal biopsy findings
MEST-C T score by 1 increase	1	0.57	1.73	0.98
*Treatment Intervention*
Long-term prednisolone use	1.85	0.94	3.64	0.08
Use of RAS inhibitors	2.65	0.61	11.5	0.19

The odds ratio and 95% confidence intervals are estimated using multivariable Cox proportional hazards analysis in IgA nephropathy patients (n = 389) who were followed up for more than two years. MEST-C scores are determined according to the Oxford classification [10]. Cellular/fibro-cellular crescents are scored as absent (C0), present in at least one glomerulus (C1), or present in > 25% of glomeruli (C2). eGFR, estimated glomerular filtration rate; RAS, renin angiotensin system; FH, familial history [of renal disease]. P values < 0.05 are boldfaced

ISSN: 1471-2369