Risks associated with continuation of potentially inappropriate antihypertensive medications in older adults receiving hemodialysis

Table 2 Risk for Hospitalization and Mortality Associated with Antihypertensive PIM Use

	Discontinued Medication	Continued Medication
Hospitalization
Total in Analysis	2060	3920
Total person time at risk (person years)	2525.4	5161.5
No. of Events	4203	7939
Rate-per-person-years	1.66 (1.61, 1.71)	1.54 (1.44, 1.64)
Unadjusted RR	Reference	0.87 (0.80, 0.93)
Adjusted RR^a	Reference	0.93 (0.86, 1.00)
Mortality
Total in Analysis	2061	3920
No. of Events (%)	431 (21%)	679 (17%)
Unadjusted HR	Reference	0.77 (0.69, 0.87)
Adjusted HR^a	Reference	0.89 (0.78, 1.02)

Abbreviations: PIM potentially inappropriate medications, CI confidence interval, HR hazard ratio, RR rate ratio
^aModels were adjusted for demographics, dual Medicare and Medicaid eligibility, comorbidity index, diabetes, ESRD cause, hospitalization count in prior 12 months, pre-dialysis nephrology care, facility for-profit status/region, nursing home residence, and functional limitation. Due to its recurrent nature, negative binomial regression was used to model hospitalization yielding rate ratios. Cox proportional hazards regression was used to model mortality yielding hazard ratios

ISSN: 1471-2369