Skip to main content

Table 4 Effect of CKD and dietary L-glutamine supplementation on expression of mRNAs encoding regulatory enzymes of taurine biosynthesis and taurine transporters in rat liver on Day 14 (i.e. 28 days after surgery)

From: Hepatic cysteine sulphinic acid decarboxylase depletion and defective taurine metabolism in a rat partial nephrectomy model of chronic kidney disease

 

Sham-operated, on Control diet, S (n = 8)

Partial nephrectomy, on Control diet, NxC (n = 8)

Partial nephrectomy, on Test diet, NxT (n = 8)

Liver

 CSAD

1.19 ± 0.35

0.91 ± 0.18

0.33 ± 0.13

 CDO

1.08 ± 0.20

0.87 ± 0.14

1.00 ± 0.14

 TauT (SLC6A6)

0.81 (0.64–0.90)

3.38 (1.86–4.33)

3.50 (1.71–15.14)*

 GAT2 (SLC6A13)

0.95 (0.87–1.08)

2.16 (1.22–14.64)

22.7 (19.73–32.84)*

  1. Feeding of experimental diets was performed from Day 1 to Day 14. Relative amounts of mRNA were normalized to the corresponding cyclophilin A signal for each sample, and relative expression is presented as (2-ΔΔCT). Data are presented as Mean ± SEM or as Median (inter-quartile range). *P < 0.05 versus Sham
Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us