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Table 2 Initial 136 mM CaCl2-infusion (ml/h) for Goal Systemic iCa 1.15 mM for “Non-Shock” Protocol

From: Regional citrate anticoagulation “non-shock” protocol with pre-calculated flow settings for patients with at least 6 L/hour liver citrate clearance

 

Systemic Albumin Level (g/dL)

Effluent Flow ml/hour

0.0–0.7 g/dL

0.8–1.2 g/dL

1.3–1.7 g/dL

1.8–2.2 g/dL

2.3–2.7 g/dL

2.8–3.2 g/dL

3.3–3.7 g/dL

3.8–4.2 g/dL

4.3–4.7 g/dL

4.8–5.2 g/dL

<=1400

16

17

17

18

19

19

20

20

21

21

1401–1700

20

20

21

22

23

23

24

25

25

26

1701–2000

23

24

25

26

27

28

28

29

30

31

2001–2300

26

27

28

30

31

32

32

33

34

35

2301–2600

32

33

34

35

37

38

39

40

41

42

2601–2900

35

37

38

39

41

42

43

44

45

46

2901–3200

38

40

42

43

44

46

47

48

50

51

3201–3500

42

43

45

47

48

50

51

53

54

55

3501–3800

45

47

48

50

52

54

55

57

58

60

3801–4100

48

50

52

54

56

57

59

61

63

64

4101–4400

51

53

55

57

59

61

63

65

67

68

  1. Footnote: For patients with expected good to fair citrate metabolism the initial Ca infusion rate is prescribed by the nephrology team based on the effluent flow row (=QACDA+ QD+ QRF+ Net UF) and the last measured systemic serum albumin column. Calcium replacement is the product of the plasma Ca-clearance times the goal serum total Ca level. The patient’s serum albumin level determines the target plasma total Ca level needed to keep the plasma iCa around 1.05–1.25 mmol/L with systemic citrate clearance estimated at about 15 L/hour and systemic citrate level estimated in the 0.7–1.4 mM range. To target a higher systemic iCa of 1.3 mM (at the ICU team’s discretion) simply multiply by 1.13 the initial Ca-infusion rate derived from Table 2 (which is designed for goal systemic iCa 1.15 mM)
  2. Abbreviations: g/dL grams per deciliter, ml/hour milliliter per hour, QCa Calcium infusion rate, QACDA Acid citrate dextrose anticoagulant infusion rate, QD dialysate flow rate, QRF replacement fluid flow rate, Net UF machine set net ultrafiltration rate