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Table 5 Commercially available citrate solution and CKRT fluids and compounded Ca-infusion used with the “non-shock” CVVHDF-RCA protocol

From: Regional citrate anticoagulation “non-shock” protocol with pre-calculated flow settings for patients with at least 6 L/hour liver citrate clearance

Solute

ACDA

Citrate

113 mM

CKRT Fluid (1)

BBraun 4553

2 K/25Bic

CKRT Fluid (2)

BBraun 4556

4 K/25Bic

136 mM CaCl2

in 0.9% Saline

Calcium (mM)

 

0

0

136

Magnesium (mM)

 

0.75

0.75

0

Chloride (mM)

 

114.5

116.5

395

Glucose (mM)

124

0

0

0

Sodium (mM)

225

136

136

123

Citric Acid (mM)

38

   

Citrate3− (mM)

75

   

Potassium (mM)

 

2

4

 

Bicarbonate (mM)

 

25

25

 
  1. Footnote: In our institution, we customize the commercial CKRT fluid 1 by spiking with K-phosphate or K-chloride to final K 2, 3, or 4 mmol/L and phosphate 2.1 or 4.2 mg/dL and with NaHCO3 (default spiking: none) to final Na 136 (no added HCO3), 141 or 146 mM and HCO3 25, 30, or 35 mM (for patients who need a systemic HCO3 level > 25 and/or have moderately impaired citrate metabolism with or without moderate lactic acidosis < 10 mM). In hospitals without pharmacy support for CKRT fluid compounding the CKRT fluid 2 can be used for 4 K CKRT and phosphate could be supplemented as 15 mmol of Na-phosphate intravenous piggyback every 8 to 12 h for most patients
  2. Abbreviations: mM millimolar, ACDA Acid citrate dextrose A, K Potassium, Bic Bicarbonate, CaCl2 Calcium chloride