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Table 2 Cox proportional hazard model for the renal outcome in 1239 IgAN patients

From: Cigarette smoking may accelerate the progression of IgA nephropathy

Parameters

Univariate

Multivariate

HR (95%CI)

HR (95%CI)

Smoker

1.97 (1.37–2.83) **

1.58 (1.02–2.46) *

Female

0.64 (0.47–0.89) **

2.00 (1.29–3.10) **

Hypertension

3.22 (2.32–4.45) **

1.50 (1.04–2.16) *

SBP

1.03 (1.02–1.03) **

 

DBP

1.04 (1.03–1.05) **

 

Serum creatinine

1.02 (1.01–1.02) **

1.01 (1.09–1.01) **

eGFR

0.96 (0.96–0.97) **

 

Urine protein

1.10 (1.06–1.15) **

1.04 (0.97–1.10)

Oxford Classification

 M1

2.38 (1.41–4.01) **

1.61 (0.95–2.73)

 E1

1.22 (0.62–2.40)

0.63 (0.31–1.31)

 S1

2.97 (2.03–4.37) **

1.59 (1.06–2.39) *

 T1/T2

7.65 (5.51–10.60) **

3.13 (2.09–4.67) **

 C1/C2

1.30 (0.92–1.84)

1.07 (0.74–1.55)

  1. Note: * stands for p < 0.05, ** stands for p < 0.01
  2. Abbreviations: HR Hazard ratio, 95% CI 95% confidence interval, SBP Systolic blood pressure, DBP Diastolic blood pressure, eGFR Estimated glomerular filtration rate, M Mesangial proliferation, E Endocapillary proliferation, S Segmental sclerosis, T Tubular atrophy/interstitial fibrosis, C Crescents, IgAN Immunoglobulin A nephropathy