Table 4 Independent risk factors for death using a stepwise Cox regression model

Stage 1: Pre-admission factors

  Age (in decades) 

1.37

1.20 – 1.56

<0.0001

  Clinical frailty score

1.18

1.07 – 1.31

0.002

  Obesity

1.57

1.05 – 2.34

0.029

Stage 2: Pre-admission and admission factors (including community-acquired AKI)

  Age (in decades)

1.33

1.16 – 1.53

<0.0001

  Clinical frailty score

1.24

1.12 – 1.38

<0.0001

  Admission O2 saturation

0.95

0.92 – 0.97

<0.0001

  Admission respiratory rate

1.06

1.03 – 1.08

<0.0001

  Admission CRP (per 10 units)

1.03

1.01 – 1.04

0.005

Stage 3: Pre-admission, admission and inpatient factors (including hospital-acquired AKI)

  Age (in decades)

1.35

1.18 – 1.55

<0.0001

  Clinical frailty score

1.26

1.13 – 1.41

<0.0001

  Admission O2 saturation

0.95

0.93 – 0.98

<0.0001

  Admission respiratory rate

1.04

1.02 – 1.07

<0.0001

  Hospital-acquired AKI

4.64

2.98 – 7.23

<0.0001

  Peak CRP (per 10 units)

1.05

1.03 - 1.06

<0.0001

  Trough lymphocytes

1.14

1.03 – 1.26

0.015