Table 4 Subgroup analyses examining the association of urine osmolality with eGFR and log ACR
Exposure | Kidney function/injury | |||||
|---|---|---|---|---|---|---|
eGFR (mL/min/1.73m2) | Log-transformed ACR | |||||
Unadjusted | Multivariablea | p-value* | Unadjusted | Multivariablea | p-value* | |
ß (95% CI) | ß (95% CI) | ß (95% CI) | ß (95% CI) | |||
Urine Osmolality (mOsm/kg)b | ||||||
eGFR (mL/min/1.73m2) | ||||||
< 60 | 0.64 (-0.05, 1.33) | 0.50 (0.05, 0.96) | 0.016 | -0.06 (-0.20, 0.07) | -0.06 ( -0.21, 0.09) | 0.532 |
(N = 172, 2.3%; mean 52.0 ± 0.6 mL/min/1.73m2) | ||||||
≥ 60 | 0.46 (0.23, 0.68) | -0.19 ( -0.36, -0.01) | -0.01 (-0.02, -0.00) | -0.00 (-0.01, 0.01) | ||
(N = 7,201, 97.7%; mean 99.8 ± 0.4 mL/min/1.73m2) | ||||||
Albuminuria (mg/gm)c | ||||||
Yes | 2.03 (1.07, 2.99) | 0.43 ( -0.33, 1.20) | 0.060 | -0.02 (-0.06, 0.02) | -0.05 (-0.09, -0.00) | 0.959 |
(N = 489, 6.6%; mean 169.3 ± 20.7 mg/gm) | ||||||
No | 0.48 (0.24, 0.71) | -0.17 (-0.33, -0.01) | -0.01 (-0.02, -0.01) | -0.00 (-0.01, 0.01) | ||
(N = 6,884, 93.4%; mean 6.8 ± 0.1 mg/gm) | ||||||