Table 4 Odds Ratio and 95 % confidence intervals of the association between liver fibrosis score (FIB-4) and low eGFR (eGFR calculated from CKD-EPI cystatin C equation) and increased urine albumin-to-creatinine ratio (UACR)

Regression models	Weighted % (SD)	Low eGFR	Increased UACR
Regression models	Weighted % (SD)	OR and 95 %CI	OR and 95 %CI
Unadjusted model
Low FIB-4	86.5 (0.45)	1.00	1.00
Moderate FIB-4	12.5 (0.43)	7.90 (5.73, 10.89)	1.87 (1.58, 2.23)
High FIB-4	1.0 (0.13)	5.38 (1.99, 14.53)	4.46 (2.82, 7.05)
Model 1
Low FIB-4	86.5 (0.45)	1.00	1.00
Moderate FIB-4	12.5 (0.43)	1.37 (0.98, 1.93)	1.12 (0.92, 1.36)
High FIB-4	1.0 (0.13)	0.67 (0.24, 1.90)	2.47 (1.54, 3.96)
Model 2
Low FIB-4	86.5 (0.45)	1.00	1.00
Moderate FIB-4	12.5 (0.43)	1.35 (0.96, 1.90)	1.18 (0.97, 1.43)
High FIB-4	1.0 (0.13)	0.65 (0.23, 1.83)	2.62 (1.63, 4.20)
Model 3
Low FIB-4	86.5 (0.45)	1.00	1.00
Moderate FIB-4	12.5 (0.43)	1.31 (0.93, 1.83)	1.15 (0.94, 1.41)
High FIB-4	1.0 (0.13)	0.60 (0.21, 1.75)	2.54 (1.56, 4.13)

Liver fibrosis score (FIB-4): low (FIB-4 < 1.3), moderate (FIB-4: 1.3–2.67), and high (FIB-4 > 2.67)
Low eGFR defined as eGFR < 60 ml/min/1.73 m²
Increased UACR defined as UACR > 17 mg/g in men and > 25 mg/ g in women
Model 1 adjusted for age, sex, Hispanic/Latino background, and study site
Model 2 adjusted for age, sex, Hispanic/Latino background, study site, and metabolic syndrome
Model 3 adjusted for age, sex, Hispanic/Latino background, study site, metabolic syndrome, education attainment, alcohol consumption, cigarette smoking, having health insurance, use of angiotensin converting enzyme inhibitors/angiotensin receptor blockers, and corticosteroids

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