Fig. 1
From: Chronic kidney disease linked to SARS-CoV-2 infection: a case report
Histopathology and immunodetection assays in formalin-fixed paraffin embedded kidney biopsy from a 69-year-old patient suffering from chronic COVID-19 infection. A (HES, × 200) and B (PAS, × 200): grade I interstitial fibrosis associated with grade I tubular atrophy without glomerular damage; focal desquamation of the brush border of epithelial cells of proximal convoluted tubules (arrow), associated with focal sloughing of epithelial cells of proximal convoluted tubules with intra-tubular cell casts (arrowheads); C, D, E and I (× 600): co-detection of SARS-CoV-2 nucleoprotein (green fluorescence) and protease-3C (red fluorescence) in epithelial cells of proximal convoluted tubules (arrows) using anti-NP and anti-Prot3C mAb; F, G, H and J (× 600): co-detection of SARS-CoV-2 nucleoprotein (green fluorescence) and protease3C (red fluorescence) in the glomerular apparatus (arrows) using anti-NP and anti-Prot3C mAb; K (× 200): ACE2 detection on the brush border of epithelial cells of proximal convoluted tubules (arrowhead) using anti-ACE2 mAb. Positive detection is shown by brown staining; L (× 200): A antigen expression in glomerular capillary walls (arrowhead) and distal convoluted tubules (arrow) using anti-A mAb. Positive detection is shown by brown staining; M (× 200): Lex antigen expression in proximal convoluted tubules (arrowhead) and podocytes (arrow) using anti-Lex mAb. Positive detection is shown by brown staining; N (× 200): sialyl-Lex antigen expression in proximal convoluted tubules (arrowhead) and podocytes (arrow). Positive detection is shown by brown staining