Skip to main content

Table 1 Baseline clinical and pathological characteristics according to Hb levels and IFTA status

From: Impact of the relationship between hemoglobin levels and renal interstitial fibrosis on long-term outcomes in type 2 diabetes with biopsy-proven diabetic nephropathy

 

All

Baseline Hb (g/dL)

IFTA (score)

Mild IFTA

Severe IFTA

 

Lowest tertile

Middle tertile

Highest tertile

p

Mild

Severe

p

Lowest tertile

of Hb

Middle tertile

of Hb

Highest tertile

of Hb

p

Lowest tertile

of Hb

Middle tertile

of Hb

Highest tertile

of Hb

p

 

≤10.7

10.8–13.2

≥13.3

 

≤1

≥2

   

n

233

76

78

79

 

82

151

 

15

26

41

 

61

52

38

 

Clinical covariates

 Hb (g/dL), mean (SD)

12.1

9.4

12.0

14.7

<0.01

13.0

11.6

<0.01

9.4

12.2

14.8

<0.01

9.4

12.0

14.6

<0.01

(2.4)

(1.1)

(0.7)

(1.1)

 

(2.3)

(2.3)

 

(1.5)

(0.6)

(1.2)

 

(1.1)

(0.7)

(0.9)

 

 Age (years), mean (SD)

58.0

61.4

59.2

53.5

<0.01

55.2

59.5

<0.05

60.9

59.0

50.6

<0.05

61.5

59.4

56.5

<0.05

(11.5)

(9.3)

(11.4)

(12.1)

 

(14.3)

(9.3)

 

(9.0)

(14.2)

(14.7)

 

(9.4)

(9.9)

(7.6)

 

 Male

66.1

61.8

56.4

79.7

<0.01

63.4

67.5

0.52

66.7

50.0

70.7

0.22

60.7

59.6

89.5

<0.01

 Serum creatinine (mg/dL), mean (SD)

1.4

2.2

1.3

0.9

<0.01

0.9

1.7

<0.01

1.3

0.9

0.8

<0.01

2.4

1.4

1.0

<0.01

(1.3)

(1.8)

(1.0)

(0.3)

 

(0.4)

(1.6)

 

(0.5)

(0.4)

(0.3)

 

(1.9)

(1.2)

(0.4)

 

 eGFR (mL/min/1.73m2), mean (SD)

56.8

35.6

57.5

76.4

<0.01

74.0

47.4

<0.01

47.2

70.2

86.0

<0.01

32.8

51.1

66.1

<0.01

(30.8)

(21.2)

(28.0)

(28.2)

 

(32.7)

(25.4)

 

(21.8)

(34.1)

(29.1)

 

(20.2)

(22.1)

(23.3)

 

 eGFR <60 mL/min/1.73m2

60.5

86.8

61.5

34.2

<0.01

41.5

70.9

<0.01

80.0

53.8

19.5

<0.01

88.5

65.4

50.0

<0.01

 Micro/macroalbuminuria or mild/severe proteinuria

85.0

96.1

89.7

69.6

<0.01

81.7

86.8

0.30

86.7

92.3

73.2

0.12

98.4

88.5

65.8

<0.01

 Macroalbuminuria or severe proteinuria

63.1

89.5

61.5

39.2

<0.01

41.5

74.8

<0.01

73.3

42.3

29.3

<0.05

93.4

71.2

50.0

<0.01

 HbA1c (%), mean (SD)

7.7

6.5

8.3

8.2

<0.01

7.8

7.7

0.52

6.2

8.4

7.9

<0.01

6.6

8.2

8.5

<0.01

(2.2)

(1.7)

(2.2)

(2.3)

 

(2.1)

(2.3)

 

(1.1)

(2.2)

(2.1)

 

(1.8)

(2.3)

(2.4)

 

 Systolic blood pressure (mmHg), mean (SD)

140.5

148.8

139.0

134.1

<0.01

131.7

145.4

<0.01

140.4

129.0

130.3

0.15

150.8

144.0

138.2

<0.05

(21.6)

(22.7)

(20.8)

(18.8)

 

(20.0)

(21.0)

 

(22.3)

(18.6)

(19.5)

 

(22.4)

(20.2)

(17.2)

 

 Diastolic blood pressure (mmHg), mean (SD)

76.6

77.0

75.3

77.4

0.62

74.8

77.6

0.07

75.6

71.0

76.9

0.21

77.3

77.5

78.1

0.96

(12.4)

(12.4)

(13.0)

(11.7)

 

(13.5)

(11.6)

 

(18.9)

(10.2)

(12.7)

 

(10.5)

(13.7)

(10.6)

 

 Total cholesterol (mg/dL), mean (SD)

216.3

223.0

224.5

201.9

0.47

206.6

221.7

0.45

248.7

197.6

196.9

0.36

216.6

238.5

207.3

0.65

(83.7)

(94.1)

(98.3)

(50.3)

 

(60.7)

(94.0)

 

(99.1)

(44.6)

(44.4)

 

(92.5)

(114.9)

(56.2)

 

 Body mass index (kg/m2), mean (SD)

23.3

22.9

23.0

24.1

0.20

23.5

23.3

0.99

21.3

22.9

24.7

<0.05

23.3

23.1

23.4

0.77

(3.7)

(3.4)

(3.1)

(4.3)

 

(4.3)

(3.3)

 

(2.8)

(3.2)

(4.9)

 

(3.5)

(3.1)

(3.4)

 

Pathological covariates

 IFTA (0–3), mean (SD)

1.9

2.2

1.9

1.5

<0.01

0.8

2.5

<0.01

0.9

0.9

0.7

0.09

2.6

2.5

2.4

0.37

(0.9)

(0.8)

(0.9)

(1.0)

 

(0.4)

(0.5)

 

(0.3)

(0.4)

(0.5)

 

(0.5)

(0.5)

(0.5)

 

 Diffuse lesion (0–4), mean (SD)

2.2

2.6

2.3

1.7

<0.01

1.6

2.4

<0.01

2.3

1.7

1.4

<0.01

2.7

2.5

2.0

<0.01

(0.9)

(0.6)

(1.0)

(0.9)

 

(0.8)

(0.9)

 

(0.7)

(0.9)

(0.6)

 

(0.6)

(1.0)

(1.0)

 

 Nodular lesion

48.5

68.5

53.2

25.3

<0.01

30.5

58.5

<0.01

46.7

42.3

17.1

<0.05

74.1

58.8

34.2

<0.01

 Exudative lesion

34.1

52.1

33.8

17.7

<0.01

19.5

42.4

<0.01

46.7

19.2

9.8

<0.01

53.4

41.2

26.3

<0.05

 Mesangiolysis

27.2

39.7

29.9

12.8

<0.01

16.0

33.6

<0.01

20.0

23.1

9.8

0.31

44.8

33.3

16.2

<0.05

 Interstitial cell infiltration (0–2), mean (SD)

1.1

1.2

1.2

1.0

0.35

0.8

1.3

<0.01

0.9

1.0

0.7

0.11

1.2

1.3

1.4

0.19

(0.5)

(0.4)

(0.5)

(0.7)

 

(0.6)

(0.5)

 

(0.3)

(0.5)

(0.6)

 

(0.4)

(0.4)

(0.5)

 

 Arteriolar hyalinosis (0–3), mean (SD)

2.0

2.2

2.1

1.7

<0.01

1.5

2.3

<0.01

1.7

1.8

1.2

<0.05

2.3

2.3

2.2

0.77

(1.0)

(0.9)

(0.9)

(1.1)

 

(1.0)

(0.8)

 

(1.0)

(0.9)

(1.0)

 

(0.8)

(0.8)

(0.9)

 

 Arteriosclerosis (0–2), mean (SD)

1.3

1.5

1.4

1.1

<0.01

1.1

1.4

<0.05

1.4

1.4

0.9

0.05

1.5

1.5

1.3

0.11

(0.7)

(0.5)

(0.6)

(0.7)

 

(0.8)

(0.6)

 

(0.5)

(0.6)

(0.8)

 

(0.5)

(0.6)

(0.6)

 
  1. Data are mean (SD) or percent. Abbreviations: eGFR estimated glomerular filtration rate; Hb hemoglobin; IFTA interstitial fibrosis and tubular atrophy
Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us