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Table 2 Pathological covariates identified by regression analyses associated with baseline Hb levels

From: Impact of the relationship between hemoglobin levels and renal interstitial fibrosis on long-term outcomes in type 2 diabetes with biopsy-proven diabetic nephropathy

 

Linear regression analyses associated with Hb levels

Binary logistic regression analyses associated with the lowest tertile of Hb

 

Univariate

Multivariate

Univariate

Multivariate

Pathological covariates

R

p

Standardized coefficient B

(95 % CI)

p

Odds ratio

(95 % CI)

p

Odds ratio

(95 % CI)

p

IFTA (score + 1)

–0.327

< 0.01

–0.165

(

–0.812

,

–0.007

)

< 0.05

1.89

(

1.36

,

2.62

)

< 0.01

1.58

(

1.01

,

2.47

)

< 0.05

Diffuse lesion (score + 1)

–0.396

< 0.01

–0.172

(

–0.863

,

0.006

)

0.05

2.26

(

1.59

,

3.22

)

< 0.01

1.58

(

0.95

,

2.62

)

0.08

Presence of nodular lesion

–0.366

< 0.01

-0.141

(

–1.47

,

0.137

)

0.10

3.39

(

1.88

,

6.10

)

< 0.01

1.53

(

0.66

,

3.57

)

0.32

Presence of exudative lesion

–0.293

< 0.01

–0.095

(

–1.184

,

0.249

)

0.20

3.15

(

1.76

,

5.64

)

< 0.01

1.78

(

0.86

,

3.69

)

0.12

Presence of mesangiolysis

–0.261

< 0.01

–0.058

(

–1.09

,

0.472

)

0.44

2.44

(

1.33

,

4.47

)

< 0.01

1.07

(

0.49

,

2.34

)

0.87

Interstitial cell infiltration (score + 1)

–0.123

0.06

–0.016

(

–0.687

,

0.547

)

0.82

1.31

(

0.78

,

2.20

)

0.30

0.96

(

0.45

,

2.01

)

0.91

Arteriolar hyalinosis (score + 1)

–0.225

< 0.01

0.036

(

–0.263

,

0.436

)

0.63

1.40

(

1.04

,

1.89

)

< 0.05

0.84

(

0.56

,

1.24

)

0.38

Arteriosclerosis (score + 1)

–0.229

< 0.01

–0.124

(

–0.917

,

0.014

)

0.06

1.64

(

1.04

,

2.59

)

< 0.05

1.42

(

0.82

,

2.48

)

0.22

  1. Abbreviations: CI confidence interval; Hb hemoglobin; IFTA interstitial fibrosis and tubular atrophy