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Table 3 Adjusted HR for the outcomes according to the tertile of baseline Hb by IFTA status

From: Impact of the relationship between hemoglobin levels and renal interstitial fibrosis on long-term outcomes in type 2 diabetes with biopsy-proven diabetic nephropathy

 

Mild IFTA (score ≤ 1)

Severe IFTA (score ≥ 2)

 

Highest tertile of Hb

Middle tertile of Hb

Lowest tertile of Hb

Highest tertile of Hb

Middle tertile of Hb

Lowest tertile of Hb

 

≥ 13.3

10.8–13.2

≤ 10.7

≥ 13.3

10.8–13.2

≤ 10.7

Participants, n

41

26

15

38

52

61

Renal composite events

  Events, n (%)

15 (36.6)

10 (38.5)

8 (53.3)

14 (36.8)

34 (65.4)

38 (62.3)

  Model 1

1 (reference)

0.95 (0.42–2.18)

2.64 (1.06–6.57)*

1 (reference)

3.19 (1.63–6.25)**

7.57 (3.49–16.41)**

  Model 2

1 (reference)

0.87 (0.37–2.04)

2.93 (1.17–7.30)*

1 (reference)

3.17 (1.61–6.22)**

7.09 (3.23–15.54)**

  Model 3

1 (reference)

0.38 (0.12–1.20)

6.21 (1.99–19.40)**

1 (reference)

5.40 (2.39–12.18)**

11.71 (4.84–28.31)**

All-cause mortality

  Events, n (%)

6 (14.6)

3 (11.5)

1 (6.7)

4 (10.5)

13 (25.0)

15 (24.6)

  Model 1

1 (reference)

0.67 (0.17–2.71)

0.52 (0.06–4.47)

1 (reference)

2.75 (0.87–8.75)

8.93 (2.68–29.74)**

  Model 2

1 (reference)

0.53 (0.11–2.65)

0.55 (0.06–4.79)

1 (reference)

2.78 (0.88–8.84)

8.66 (2.59–29.03)**

  Model 3

1 (reference)

0.09 (0.002–3.65)

0.70 (0.02–29.74)

1 (reference)

4.47 (1.16–17.22)*

8.85 (1.78–44.15)**

  1. Model 1: Adjusted for age, gender, estimated glomerular filtration rate, and presence of albuminuria [proteinuria]. Model 2: Further adjusted for HbA1c and systolic blood pressure. Model 3: Further adjusted for pathological covariates excluding IFTA. *p < 0.05 vs. the highest tertile of Hb. **p < 0.01 vs. the highest tertile of Hb. Abbreviations: Hb hemoglobin; IFTA interstitial fibrosis and tubular atrophy