Fig. 1

Digenic Inheritance of Rare Variants in LAMA2 and LOXL4 in a Family with Autosomal Dominant FSGS. Individuals with dot indicates microalbuminuria and unclear affectation status. A Exome Sequencing was performed in 3 affected members (6238, 6237, 6463) of family FSGS 15. B Five heterozygous rare variants were identified and sequenced in each relative, with LAMA2 (*) and LOXL4 ( +) segregating in affected individuals. C These variants affect highly conserved residues across species and are predicted to be deleterious by prediction programs. gnomAD v.2.1.1 accessed May 3, 2020