From: Prevalence and risk factors of chronic kidney disease in an HIV positive Mexican cohort
Variable | Without CKD n = 73 | With CKD n = 19 | Relative Risk (95%CI) | P-value |
---|---|---|---|---|
Age (years) median/IQR | 30 (26–36) | 34 (31–44) | - | 0.028 |
Age > 30 years (n/%) | 37 (50) | 16 (84) | 3.9 (1.2–13) | 0.008 |
Gender | ||||
Female (n/%) | 4 (6) | 1 (5.5) | 0.87 (0.14–5.3) | ns |
Male (n/%) | 69 (94) | 18 (94.5) | 0.88 (0.14–5.4) | ns |
Tobacco (n/%) | 42 (57) | 13 (68) | 1.5 (0.61–3.5) | ns |
Drugs (n/%) | 41 (56) | 11 (59) | 1.1 (0.47–2.4) | ns |
Alcohol (n/%) | 56 (77) | 15 (78) | 1.1 (0.41–3) | ns |
Type 2 Diabetes Mellitus (n/%) | 3 (4.1) | 0 | - | - |
Arterial hypertension | 0 | 1 (5.2) | - | - |
HIV-1 Viral Load (cop/mL) Median/IQR | 52,000 (24,650–111,000) | 169,000 (73,700–453,847) | - | 0.001 |
Viral Load HIV-1 (≥ 100,000 cop/mL) | 24 (32) | 12 (63) | 2.7 (1.2–6.1) | 0.019 |
CD4+ T cells count (cells/μL) Median/IQR | 323 (161–552) | 163 (58–300) | - | 0.003 |
CD4+ T cells < 200 cells/μL (n/%) | 32 (43) | 15 (79) | 4 (1.2–13) | 0.007 |
CD4/CD8 ratio (median/IQR) | 0.30 (0.14–0.51) | 0.20 (0.09–0.33) | - | 0.022 |
Clinical stage at baseline: | ||||
Stage A | 43 (58.9) | 7 (36) | 0.56 (0.24–1.3) | ns |
Stage B | 20 (27.4) | 3 (15.7) | 0.56 (0.18–1.8) | ns |
Stage C | 10 (13.7) | 9 (47.3) | 3.5 (1.9–7.3) | 0.002 |
Coinfections | ||||
Hepatitis B virus | 2 (2.7) | 0 | - | - |
Hepatitis C virus | 2 (2.7) | 4 (21) | 3.8 (1.8–7.9) | 0.015 |
M. tuberculosis | 2 (2.7) | 5 (26) | 4.3 (2.2–8.5) | 0.003 |
Syphilis (VDRL +) | 23 (32) | 5 (26) | 0.82 (0.33–2) | ns |