Table 1 Baseline demographic data and outcomes stratified by quartiles of delta FGF23 value

Delta cFGF23 RU/mL/year

11.9 (−3 to 57.6)

−13.9 (− 32.3 to −6.7)

3.3 (0.75 to 6.7)

26.4 (17.5 to 37.1)

168.5 (85.4 to 407.2)

< 0.001

Age, years

62 (52-71)

62 (50-71)

62 (52-71)

64 (55-70)

61 (52-71)

0.968

Sex, (Male)

245 (63.1%)

56 (57.7%)

70 (72.2%)

58 (59.8%)

61 (63%)

0.166

Ethnicity, (Caucasian)

370 (95.4%)

93 (95.9%)

91 (93.8%)

94 (96.9%)

92 (94.8%)

0.623

Current or former smoker

226 (58.2%)

52 (53.6%)

51 (52.6%)

58 (59.8%)

65 (67%)

0.151

Diabetes

97 (25%)

21 (21.6%)

22 (22.7%)

27 (27.8%)

27 (27.8%)

0.639

Prior cardiovascular event

84 (21.6%)

21 (21.6%)

22 (23.7%)

20 (20.6%)

21 (21.6%)

0.963

Heart failure at baseline

36 (9.3%)

11 (11.3%)

9 (9.3%)

9 (9.3%)

7 (7.2%)

0.806

Mean baseline systolic blood pressure (mmHg)

135 (123-150)

133 (117-150)

135 (123-150)

139 (129-152)

133 (123-150)

0.183

 Diabetic nephropathy

52 (13.4%)

12 (12.4%)

5 (5.2%)

16 (16.5%)

19 (19.6%)

 Hypertension

48 (12.4%)

11 (11.3%)

12 (12.4%)

15 (15.5%)

10 (10.3%)

 Renovascular disease

49 (12.6%)

16 (16.5%)

15 (15.5%)

7 (7.2%)

11 (11.3%)

 Glomerulonephritis

87 (22.4%)

29 (29.9%)

23 (23.7%)

16 (16.5%)

19 (19.6%)

0.004

 ADPKD

32 (8.2%)

5 (5.2%)

4 (4.1%)

11 (11.3%)

12 (12.4%)

 Other

59 (15.2%)

10 (10.3%)

24 (24.7%)

14 (14.4%)

11 (11.3%)

 Unknown

28 (7.21%)

6 (6.2%)

9 (9.3%)

7 (7.2%)

6 (6.2%)

 cFGF23 (RU/mL)

162 (101-244)

218 (129-332)

103 (78-160)

141 (100-182)

211 (157-321)

< 0.001

 Creatinine (mmol/L)

180 (140-241)

189 (140-252)

157 (126-188)

169 (133-213)

227 (181-290)

< 0.001

 MDRD eGFR (mL/min/1.73m²)

32.3 (22.9-43.3)

30 (21-45)

41.2 (30.8-51.7)

33.4 (26.1-41.8)

24.5 (18.8-33.7)

< 0.001

 Phosphate (mmol/L)

1.09 (0.95 − 1.25)

1.07 (.094-1.27)

1.02 (0.88-1.16)

1.09 (0.93-1.24)

1.16 (1.01-1.31)

0.001

 Calcium (mmol/L)

2.25 (2.17-2.32)

2.27 (2.18-2.34)

2.25 (2.18-2.31)

2.25 (2.16-2.32)

2.23 (2.14-2.31)

0.198

 Albumin (g/L)

44 (42-46)

45 (42-46)

44 (42-46)

44 (41-46)

43 (41-44)

< 0.001

 Haemoglobin (g/L)

128 (117-140)

126 (116-137)

134 (124-143)

130 (120-141)

122 (111-132)

< 0.001

 PTH (pg/mL)

54 (31-101)

54 (30-94)

35.5 (25-59.5)

50 (33-101)

90 (52-178)

< 0.001

 CRP (mg/L)

3.35 (1.4-6.87)

2.8 (1.4-5.95)

2.9 (1.5-5.5)

3.9 (1.4-8.7)

3.6 (1.4-8.8)

0.333

 Urinary protein (g/24 h)

0.15 (0.06-0.43)

0.11 (0.06-0.33)

0.12 (0.06-0.30)

0.12 (0.05-0.44)

0.31 (0.16-0.57)

< 0.001

 Delta eGFR mL/min/1.73m²/year

-1.2 (−2.76 to 0.02)

−0.08 (−0.09 to 0.97)

−0.62 (−1.87 to 0.27)

−1.6 (−3.1 to −0.54)

−2.68 (−4.6 to −1.5)

< 0.001

 Death prior to RRT (%)

86 (22.2%)

15 (15.5%)

13 (13.4%)

26 (26.8%)

32 (33%)

0.002

 RRT (%)

76 (19.6%)

8 (8.2%)

6 (6.2%)

13 (13.4%)

49 (50.5%)

< 0.001

 Total CV events during Follow-up (%)

52 (13.4%)

10 (10.3%)

9 (9.3%)

19 (19.6%)

14 (14.4%)

0.138

 Follow up time (months)

70 (52.6-96.8)

69 (53-97)

89 (59-101)

83 (55-101)

57 (43-75)

< 0.001