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Table 4 Distribution of the LDLR rs688 polymorphism according to the model of inheritance

From: LDLR gene polymorphism (rs688) affects susceptibility to cardiovascular disease in end-stage kidney disease patients

LDLR rs688

CVD+ subgroup

CVD- subgroup

OR (95% CI)

p value

C / T genotypes

(n = 552)

(n = 248)

 

Codominant model

 CC

60

124

ref.

–

 CT

326

98

6.87 (4.69–10.07)a

< 0.0001

 TT

166

26

13.19 (7.87–22.09)a

<  0.0001

Dominant model

 CC

60

124

ref.

–

 CT + TT

492

124

8.2 (5.68–11.82)a

< 0.0001

Recessive model

 CC + CT

386

222

ref.

–

 TT

166

26

3.67 (2.35–5.73)b

< 0.0001

  1. LDLR Low density lipoprotein receptor. CVD Cardiovascular disease. Genotype distribution is shown as numbers (%). Odds ratio is referred to aCC homozygote and bCC + CT genotypes
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BMC Nephrology

ISSN: 1471-2369

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