Table 4 Fluid overloaded and acute kidney injury phenotypes and characteristics
From: Renal angina index predicts fluid overload in critically ill children: an observational cohort study
Demographics | FO+/AKI+ | FO−/AKI+ | FO+/AKI- | FO−/AKI- | P-value |
|---|---|---|---|---|---|
N = 12 | N = 21 | N = 15 | N = 91 | ||
Male | 4 (33%) | 13 (62%) | 7 (47%) | 44 (48%) | 0.45 |
Age (y) | 3.5 (1.575–12.5) | 7 (2–13) | 0.75 (0.25–1.7) | 6.49 (2–13) | 0.003 |
PRISM III | 14.5 (11–25.5) | 9 (7–16) | 4 (2–8) | 5 (2–9) | < 0.001 |
Mechanical Vent | 9 (75%) | 14 (67%) | 4 (27%) | 46 (51%) | 0.041 |
CRRT | 9 (75%) | 1 (5%) | 1 (7%) | 0 (0%) | < 0.001 |
Transplant | 2 (17%) | 2 (10%) | 1 7%) | 4 (4%) | 0.39 |
Day 3 AKI Status | |||||
 None | 0 (0%) | 0 (0%) | 13 (87%) | 75 (82%) | < 0.001 |
 Stage 1 | 0 (0%) | 0 (0%) | 2 (13%) | 16 (18%) | 0.084 |
 Stage 2 | 2 (17%) | 11 (52%) | 0 (0%) | 0 (0%) | < 0.001 |
 Stage 3 | 10 (83%) | 10 (48%) | 0 (0%) | 0 (0%) | < 0.001 |
 Any Stage AKI | 12 (100%) | 21 (100%) | 2 (13%) | 16 (18%) | < 0.001 |
 Severe AKI | 12 (100%) | 21 (100%) | 0 (0%) | 0 (0%) | < 0.001 |
 Day 3 FO ≥ 15% | 12 (100%) | 0 (0%) | 15 (100%) | 0 (0%) | < 0.001 |
 ICU LOS | 14.5 (9.5–21) | 6 (3–10) | 4 (2–6) | 6 (3–10) | 0.018 |
 Hospital LOS | 32.5 (24.5–72) | 16 (7–28) | 14 (6–61) | 11 (6–19) | 0.003 |
 Mortality | 2 (17%) | 2 (10%) | 0 (0%) | 5 (5%) | 0.31 |
RAI Performance of Phenotype Prediction | |||||
 Sensitivity | 100% (73.5–100) | 76.2% (52.8–91.8) | 60% (32.3–83.7) | 44% (33.6–54.8) |  |
 Specificity | 48.8% (39.9–57.8) | 48.3% (39–57.7) | 45.2% (36.2–54.3) | 22.9% (12–37.3) |  |
 AUROC | 0.74 (0.70–0.79) | 0.62 (0.52–0.73) | 0.53 (0.39–0.66) | 0.33 (0.26–0.41) |  |
 NPV | 100% (94.2–100) | 91.9% (82.2–97.3) | 90.3% (80.1–96.4) | 17.7% (9.2–29.5) |  |