Table 1 Baseline characteristics of IgAN
From: The prognostic role of heart rate recovery after exercise and metabolic syndrome in IgA nephropathy
Clinical data | HRR ≥ 23 | HRR < 23 | P |
|---|---|---|---|
Patients (n = 125) | 60 | 65 | |
Man/woman (n/%) | 36/24 (60/40) | 46/19 (71/29) | NS |
Age (year) | 51.4 ± 12.5 | 54.7 ± 13.0 | NS |
Average systolic RR (Hgmm) | 120.1 ± 0.6 | 126.7 ± 0.8 | 0.002 |
Average diastolic RR (Hgmm) | 73 ± 9.6 | 75.7 ± 9.5 | NS |
24 h pulse pressure (Hgmm) | 47.40 ± 7.96 | 51.10 ± 8.85 | 0.012 |
Diurnal index systolic (%) | 10.92 ± 5.08 | 8.36 ± 7.72 | 0.020 |
Metabolic parameters | |||
Hypertension (n, %) | 41 (68) | 53 (81) | NS |
BMI (kg/m2) | 25.17 ± 3.8 | 27.7 ± 4.8 | 0.001 |
Dyslipidaemia (n, %) | 24 (40) | 34 (52) | NS |
Carbohydrate metabolic disorder (n, %) | 9 (15) | 21 (32) | NS |
eGFR (ml/min) | 94.6 ± 29.3 | 78.9 ± 37.9 | 0.005 |
Duration of kidney disease (year) | 10.2 ± 9.7 | 8.8 ± 9.1 | NS |
Smoking (n, %) | 7 (12) | 11(17) | NS |
Metabolic syndrome (n, %) | 13 (22) | 21 (32) | NS |
Therapy | |||
ACEI/ARB (n, %) | 46 (77) | 60 (92) | NS |
BB (n, %) | 12 (20) | 19 (29) | NS |
Statin (n, %) | 16 (27) | 22 (34) | NS |
CCB (n, %) | 9 (15) | 19 (29) | NS |
Ergometry | |||
Average heart rate (beat/min) | 72.1 ± 8.8 | 76.0 ± 10.9 | 0.016 |
Stress test time (s) | 608 ± 178.3 | 550 ± 186.5 | 0.039 |
HRR (bpm) | 31.2 ± 7.4 | 15.6 ± 5.1 | < 0.001 |
CAD (Positive stress test) | 5 (8) | 12 (18) | NS |
Echocardiographic parameters | |||
LV EF (%) | 62.4 ± 6.9 | 63.2 ± 5.9 | NS |
LVMI | 103.53 ± 15.95 | 109.21 ± 21.25 | NS |
LVM (g) | 196.8 ± 41.5 | 212.1 ± 38.5 | NS |
LVEDD (cm) | 6.05 ± 6.29 | 5.57 ± 5.13 | NS |
DD (n/%) | 7 (11) | 17 (26) | < 0.001 |
E/A | 1.18 ± 0.32 | 0.93 ± 0.30 | < 0.001 |
Laboratory results | |||
Hb (g/dl) | 13.9 ± 1.6 | 13.6 ± 1.7 | NS |
MAU (mg/day) | 406 ± 578.6 | 504 ± 642.3 | NS |
HUS (umol/l) | 303 ± 97.4 | 342 ± 84.9 | 0.009 |
Total cholesterol (mmol/l) | 5.01 ± 1.28 | 4.93 ± 1.06 | NS |
HDL cholesterol (mmol/l) | 1.35 ± 0.57 | 1.20 ± 0.31 | 0.029 |
TG (mmol/l) | 1.49 ± 0.88 | 1.93 ± 1.21 | 0.012 |