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Fig. 1 | BMC Nephrology

Fig. 1

From: Longitudinal monitoring of mRNA levels of regulatory T cell biomarkers by using non-invasive strategies to predict outcome in renal transplantation

Fig. 1

Time-related trend of mRNA levels of flCTLA-4, solCTLA-4, and FOXP3 (mean±SD) in all KTRs in the post-transplant period compared to baseline mRNA values. The expression levels were monitored at 15, 60 and 365 days, and at the moment of the ACR. A significant increase between 15 days and 60 days was highlighted for CTLA-4 isoforms (flCTLA-4 RQ=0.895±0.798, *p=0.042, solCTLA-4 RQ=0.937±0.740, *p=0.048), while FOXP3 slightly decreased. Later every marker reverted to baseline levels. In case of rejection episode, flCTLA-4 expression was the highest compared to the other two molecules at the time of the adverse event 

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BMC Nephrology

ISSN: 1471-2369

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