Table 2 Comparison of immunological biomarkers (log 2^-DCT), demographic and clinical parameters in the two groups of patients with aTCMR within 1 year (n = 11) or stable transplant (n = 78)

^aFOXP3, baseline

1.580 (1.410-1.670)

1.585 (1.370-1.760)

0.909

^aFOXP3, 15d

1.150 (0.718-1.675)

1.260 (0.950-1,510)

0.999

^aFOXP3, 60d

1.345 (1.003-1.648)

1.180 (0,940-1,390)

0.284

^aFOXP3, 1y

1.320 (1.030-1.420)

1.350 (1,095-1,423)

0.776

^aflCTLA-4 baseline

0.910 (0.730-0.980)

0.810(0.600-1.008)

0.586

^aflCTLA-4 15d

0.655 (0.010-1.093)

0.570 (0.340-0.740)

0.691

^aflCTLA-4 60d

0.585 (0.320-1.020)

0.630 (0.440-0.870)

0.999

^aflCTLA-4 1y

0.870 (0.740-1.260)

0.730 (0.508-0.863)

0.210

^asolCTLA-4 baseline

0.320 (0.060-0.590)

0.235 (0.035-0.443)

0.376

^a solCTLA-4 15d

0.365 (-0.073-0.648)

-0.070 (-0.440-0.280)

0.043

^asolCTLA-4 60d

0.120 (-0.170-0.230)

0.155 (-0.190-0.363)

0.539

^asolCTLA4 1y

0.070 (-0.530-0.670)

0.110 (0.060-0.500)

0.999

Recipient gender (%):

 -males

8/11 (72.7)

57/78 (73.1)

1.000

 -females

3/11 (27.3)

21/78 (26.9)

Donor gender (%):

 -males

6/11 (54.5)

53/78 (67.9)

0.498

 -females

5/11 (45.5)

25/78 (32.1)

^bRecipient age

54.7±14.3

52.2±11.1

0.372

^bDonor age

51.8±20.4

50.8±15.3

0.747

Donor type (%):

 -brain-dead donors

11/11 (100)

73/78 (93.6)

1.000

 -living donors

0/11 (0)

5/78 (6.4)

Delayed graft function (%)

4/11 (36.4)

28/78 (35.9)

1.000

Induction (%):

 -Basiliximab

8/11 (72.7)

74/78 (94.9)

0.038

0.144

 -Anti-thymocyte globulin

3/17 (27.3)

4/78 (5.1)

Proliferation signal inhibitor (%):

 -Everolimus

5/17 (29.4)

7/72 (9.7)

0.048

3.869

 -Mycophenolic acid

12/17 (70.6)

65/72 (90.3)

Calcineurin inhibitor (%):

 -Cyclosporine

2/11 (18.2)

12/78 (15.4)

0.682

 -Tacrolimus

9/11 (81.8)

66/78 (84.6)

^bHLA Mismatches (MM)

3.8 ± 1.4

3.0±1.2

0.050

PRA n= (%)

 -Class I

2/11 (18.2)

34/78 (43.6)

0.188

 -Class II

2/11 (18.2)

25/78 (32.1)

0.493

^bTime on RRT (months)

51.5±26.6

54.7±36.1

0.963

^bCIT (min)

717.0±218.6

617.9 ±269.4

0.212

^bWIT (min)

48.0±16.5

43.4±12.1

0.416

Previous transplants (%)

1/11 (9.1)

5/78 (6.4)

0.558

Maintenance therapy change %

6/11 (54.5)

13/78 (16.7)

0.010

6.000

CMV reactivation (%)

5/11 (45.5)

17/78 (21.8)

0.131