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Table 3 Univariate and multivariate Cox regression analyses for the risk of aTCMR after kidney transplantation

From: Longitudinal monitoring of mRNA levels of regulatory T cell biomarkers by using non-invasive strategies to predict outcome in renal transplantation

VARIABLE

Univariate analysis

Multivariate analysisa

  

-2ln likelihood: 46.938

 

HR

95% CI

P

HR

95% CI

P

Baseline

      

Membrane CTLA4

1.178

0.366—3.788

0.784

—

—

—

Soluble CTLA4

2.382

0.744—7.624

0.144

   

FOXP3

0.691

0.196—2.433

0.565

—

—

—

At 15 days

      

Membrane CTLA4

1.053

0.321—3.457

0.932

—

—

—

Soluble CTLA4

3.164

0.836—11.981

0.090

3.905

0.958-15.916

0.057

FOXP3

0.698

0.202—2.408

0.569

—

—

—

At 60 days

      

Membrane CTLA4

2.537

0.480—13.404

0.273

—

—

—

Soluble CTLA4

1.431

0.362—5.661

0.609

—

—

—

FOXP3

4.343

0.868—21.715

0.074

—

—

—

At 365 days

      

Membrane CTLA4

1.898

0.160—22.480

0.611

—

—

—

Soluble CTLA4

0.711

0.056—8.955

0.792

—

—

—

FOXP3

0.749

0.095—5.895

0.783

—

—

—

Recipient age

1.007

0.963—1.053

0.758

—

—

—

Donor age

0.999

0.969—1.031

0.972

—

—

—

Recipient gender

1.128

0.363—3.506

0.835

—

—

—

Donor gender

0.930

0.337—2.567

0.889

—

—

—

Type of dialysis

0.575

0.185—1.790

0.340

—

—

—

Dialysis duration

0.752

0.398—1.424

0.382

—

—

—

CMV reactivation

2.033

0.738—5.604

0.170

—

—

—

Previous transplant

1.466

0.973—2.210

0.067

—

—

—

HLA mismatch

1.229

0.885—1.707

0.219

—

—

—

CIT (min)

0.799

0.251—2.544

0.704

—

—

—

WIT (min)

1.000

0.998—1.002

0.859

—

—

—

Type of donor

1.030

0.992—1.069

0.120

—

—

—

Type of induction

0.259

0.082—0.814

0.021

0.148

0.024-0.923

0.041

Chronic use of steroids

0.667

0.213—2.093

0.488

—

—

—

CNI (tacrolimus vs. cyclosporine)

23.310

0.011-51229.762

0.423

—

—

—

PSI (mTOR vs. mycophenolate)

3.926

1.425—10.813

0.008

7.017

1.714-28.725

0.007

Immunosuppression change

9.175

3.178—26.488

0.000

—

—

—

Infratherapeutic CNI level at 15 days

0.821

0.291—2.311

0.708

—

—

—

Infratherapeutic CNI level at 60 days

1.303

0.483—3.514

0.601

—

—

—

DGF

0.729

0.252—2.114

0.561

—

—

—

  1. a Model summary: χ2(1)=15.901, p < 0.001. Covariates initially introduced in the multivariable model and then elided were: soluble CTLA4 at 15 days, FOXP3 at 60 days
  2. Abbreviations: CI confidence intervals, CIT cold ischemia time, CMV cytomegalovirus, CNI calcineurin inhibitor, DGF delayed graft function, HLA human leukocytes antigens, HR hazard ratio, PRA panel-reactive antibodies, mTORi mammalian target of rapamycin inhibitor, PSI proliferation signal inhibitor, WIT warm ischemia time
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BMC Nephrology

ISSN: 1471-2369

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