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Table 2 Blood pro-inflammatory and anti-inflammatory cytokines

From: Blood and urinary cytokine balance and renal outcomes at cardiac surgery

Blood cytokines

Pre-op or post-op

Any day

non-CS-AKI

CS-AKI

P value

n

median

IQR

n

median

IQR

Pro-inflammatory cytokines

 sIP-10

pre-op

260

113.10

(84.93–165.81)

64

133.83

(100.77–208.24)

0.012

 sIP-10

post-op

254

101.82

(62.42–174.68)

65

125.87

(80.45–206.44)

0.046

 sIL-12p40

pre-op

260

368.87

(268.61–582.54)

64

569.18

(390.29–874.85)

< 0.001

 sIL-12p40

post-op

254

262.82

(179.13–397.17)

65

442.36

(297.27–615.77)

< 0.001

 sMK

post-op

212

979.28

(474.26–2185.78)

58

2365.00

(1074.5–4306.67)

< 0.001

 pIL-6

pre-op

254

2.17

(1.39–4.03)

64

3.03

(1.93–7.69)

0.001

 pIL-8

post-op

259

8.54

(5.74–13.65)

65

11.82

(6.84–19.38)

0.005

 pMIP-1α

pre-op

251

3.53

(2.79–4.37)

64

4.52

(3.03–5.55)

0.001

 pMIP-1α

post-op

256

4.33

(3.33–6.38)

65

6.63

(4.33–10.12)

< 0.001

 pMCP-1

pre-op

254

129.00

(105–152)

64

143.00

(110.75–171.75)

0.008

 pMCP-1

post-op

259

194.00

(139–274)

65

248.00

(183.5–350)

0.001

 pNGAL

pre-op

255

572.89

(437.04–742.77)

64

672.05

(564.33–951.71)

0.001

 pNGAL

post op

260

948.07

(646.34–1300.38)

65

1439.01

(1036.43–1902.86)

< 0.001

 pTNFα

pre-op

254

2.05

(1.66–2.54)

64

2.50

(2–2.89)

< 0.001

 pTNFα

post-op

259

2.33

(1.8–3.17)

65

3.11

(2.06–4.45)

< 0.001

Anti-inflammatory cytokines

 sTNFsr1

pre-op

260

0.33

(0.26–0.45)

64

0.52

(0.37–0.68)

< 0.001

 sTNFsr1

post-op

254

0.68

(0.52–0.85)

65

1.04

(0.79–1.4)

< 0.001

 sTNFsr2

pre-op

260

0.35

(0.24–0.56)

64

0.57

(0.37–0.85)

< 0.001

 sTNFsr2

post-op

254

0.71

(0.49–0.99)

65

1.25

(0.77–1.66)

< 0.001

 sIL-1RA

pre-op

260

60.80

(40.63–105.57)

64

81.99

(55.14–132.15)

0.005

 sIL-1RA

post-op

254

406.48

(242.34–794.63)

65

739.25

(440.03–1887)

< 0.001

 pIL-10

post-op

259

2.27

(1.48–4.64)

65

3.27

(1.85–5.69)

0.009

  1. pre-op Preoperative, post-op Postoperative, CS-AKI Cardiac surgery acute kidney injury, n Number of patients, sIP-10 Serum interferon gamma - induced protein-10, sIL-12p40 Serum interleukin-12 subunit p40, sMK Serum midkine, pIL-6 Plasma interleukin-6, pIL-8 Plasma interleukin-8, pMIP-1α Plasma macrophage inflammatory protein-1α, pMCP-1 Plasma monocyte chemotactic protein-1, pNGAL Plasma neutrophil gelatinase-associated lipocalin, pTNFα Plasma tumor necrosis factor α, sTNFsr1 Serum tumor necrosis factor soluble receptor 1, sTNFsr2 Serum tumor necrosis factor soluble receptor 1, sIL-1RA Serum interleukin-1 receptor antagonist, pIL-10 Plasma interleukin-10