Table 4 Cytokine ratios with the highest predictive ability to identify patients at risk of developing CS-AKI
From: Blood and urinary cytokine balance and renal outcomes at cardiac surgery
Any Day | |||||
|---|---|---|---|---|---|
Biomarker(s) | AUROC | CI | Sensitivity | Specificity | |
Preoperative | uIL-1RA/pIL-6 | 0.616 | 0.538–0.694 | 67.2% | 52.4% |
Postoperative | uIL-1RA/sIL-12p40 + uTNFsr2/sH-FABP + uIL-1RA/sMK | 0.824 | 0.770–0.879 | 82.8% | 67.8% |
uIL-1RA/sIL-12p40 + uTNFsr2/sH-FABP | 0.775 | 0.715–0.835 | 72.3% | 67.1% | |
uIL-1RA/sIL-12p40 + uIL-1RA/sMK | 0.784 | 0.720–0.848 | 74.1% | 69.1% | |
uTNFsr2/sH-FABP + uIL-1RA/sMK | 0.771 | 0.709–0.832 | 74.1% | 68.6% | |
uIL-1RA/sIL-12p40 | 0.725 | 0.658–0.792 | 72.3% | 63.9% | |
uTNFsr2/sH-FABP | 0.685 | 0.617–0.753 | 73.8% | 56.6% | |
uIL-1RA/sMK | 0.704 | 0.632–0.776 | 74.1% | 55.3% | |