Skip to main content

Table 2 Results of the multivariate analysis between ALB and the endpoints

From: Albumin levels predict mortality in sepsis patients with acute kidney injury undergoing continuous renal replacement therapy: a secondary analysis based on a retrospective cohort study

N (death at 28 days)

794

757

581

482

Models

Non-adjusted HR (95% CI) P value

Adjusted I HR (95% CI) P value

Adjusted II HR (95% CI) P value

Fully adjusted HR (95% CI) P value

ALB (g/dL)

0.71 (0.61–0.82) < 0.0001

0.74 (0.63–0.88) 0.0004

0.75 (0.62–0.90) 0.0024

0.72 (0.58–0.90) 0.0039

ALB tertiles

    

Low (0.00–2.20 g/dl)

Ref

Ref

Ref

Ref

Middle (2.30–2.70 g/dl)

0.87 (0.71–1.08) 0.2042

0.86 (0.69–1.08) 0.1944

0.75 (0.57–0.98) 0.0332

0.81 (0.60–1.09) 0.1700

Middle (2.80–5.90 g/dl)

0.63 (0.51–0.79) < 0.0001

0.67 (0.53–0.85) 0.0008

0.64 (0.49–0.85) 0.0019

0.65 (0.47–0.89) 0.0069

P for trend

< 0.0001

0.0006

0.0022

0.0069

N (death at 90 days)

794

790

731

482

Models

Non-adjusted HR (95% CI) P value

Adjusted I HR (95% CI) P value

Adjusted II HR (95% CI) P value

Fully adjusted HR (95% CI) P value

ALB (g/dL)

0.70 (0.61–0.80) < 0.0001

0.75 (0.65–0.87) 0.0001

0.73 (0.63–0.86) < 0.0001

0.68 (0.55–0.85) 0.0005

ALB tertiles

    

low

Ref

Ref

Ref

Ref

middle

0.83 (0.68–1.02) 0.0713

0.83 (0.68–1.02) 0.0762

0.81 (0.65–1.00) 0.0547

0.72 (0.55–0.96) 0.0253

high

0.62 (0.50–0.76) < 0.0001

0.67 (0.54–0.82) 0.0002

0.63 (0.50–0.79) < 0.0001

0.60 (0.45–0.80) 0.0005

P for trend

< 0.0001

0.0001

< 0.0001

0.0006

  1. Non-adjusted model adjusted for: None
  2. Adjusted I model (death at 28 days) adjusted for: age, sex, P, BUN, Cr, UO, SOFA score, and Indications for CRRT
  3. Adjusted I model (death at 90 days) adjusted for: age, sex, BUN, Cr, and SOFA scores
  4. Adjusted II model (death at 28 days) adjusted for: age, sex, K, HCO3, P, aCCI, BMI, SBP, DBP, MAP, MV, WBC, HGB, BUN, Cr, CRP, UO, APACHE-II score, SOFA score, Indications for CRRT, CRRT dose, and AKIN
  5. Adjusted II model (death at 90 days) adjusted for: age, sex, K, HCO3, P, aCCI, BMI, SBP, DBP, MAP, MV, WBC, HGB, BUN, Cr, GFR, UO, APACHE-II score, SOFA score, Indications for CRRT, CRRT dose, and AKIN
  6. Fully adjusted model adjusted for: all variables except ALB and the endpoints