Skip to main content

Table 1 Clinicopathologic characteristics of IgAN patients in low and high Hcy group

From: Serum homocysteine is associated with tubular interstitial lesions at the early stage of IgA nephropathy

Variable

Total (n = 337)

Hcy ≤ 10.0 (n = 114)

Hcy > 10.0 (n = 223)

P

Hcy (μmol/L)

11.6 (9.1,15.3)

8.2 (7.3,9.1)

13.7 (11.7,16.7)

< 0.001**

Age (years)

34.0 (27.5,44.0)

32.5 (27.0,39.0)

35.0 (28.0,47.0)

0.003*

Male, n (%)

135 (40.1)

27 (23.7)

108 (48.4)

< 0.001**

SBP (mmHg)

123.0 (115.0,137.5)

119.5 (110.0,131.0)

126.0 (117.0,141.0)

< 0.001**

DBP (mmHg)

80.0 (74.0,90.0)

77.5 (73.0,87.0)

82.0 (75.0,94.0)

0.002*

MAP (mmHg)

94.7 (88.7,106.3)

92.0 (86.3,99.7)

96.3 (89.3,109.7)

< 0.001**

HBP, n (%)

132 (39.2)

22 (19.3)

110 (49.3)

< 0.001**

Scr (μmol/L)

86.0 (70.0,115.5)

69.5 (61.0,82.3)

99.0 (77.0,139.0)

< 0.001**

eGFR (mL/min/1.73 m2)

88.1 (62.8,103.4)

101.4 (89.3,115.4)

75.0 (44.9,95.2)

< 0.001**

CKD stage, n (%)

   

< 0.001**

 CKD 1

156 (46.3)

82 (71.9)

74 (33.2)

 

 CKD 2

100 (29.7)

32 (28.1)

68 (30.5)

 

 CKD 3

51 (15.1)

0 (0.0)

51 (22.9)

 

 CKD 4

13 (3.9)

0 (0.0)

13 (5.8)

 

 CKD 5

17 (5.0)

0 (0.0)

17 (7.6)

 

BUN (mmol/L)

5.1 (4.3,6.9)

4.5 (3.6,5.1)

5.8 (4.7,8.0)

< 0.001**

UA (mmol/L)

390.0 (324.0,484.5)

352.5 (302.8,413.8)

413.0 (347.0,512.0)

< 0.001**

24-h urine protein (g/24 h)

0.6 (0.2,1.7)

0.5 (0.2,1.0)

0.7 (0.3,1.8)

0.101

Hb (g/L)

125.0 (114.0,139.5)

128.5 (118.8,138.0)

124.0 (111.0,142.0)

0.135

ALB (g/L)

35.0 ± 6.8

33.7 ± 7.9

35.6 ± 6.2

0.011*

Glu (mmol/L)

4.4 ± 0.6

4.4 ± 0.5

4.4 ± 0.6

0.631

CHOL (mmol/L)

5.1 (4.3,5.9)

5.1 (4.5,6.0)

5.0 (4.3,5.9)

0.262

TG (mmol/L)

1.6 ± 1.4

1.4 ± 0.9

1.7 ± 1.6

0.080

LDL (mmol/L)

3.2 (2.6,3.8)

3.2 (2.7,3.9)

3.2 (2.6,3.8)

0.386

HDL (mmol/L)

1.3 ± 0.4

1.4 ± 0.4

1.2 ± 0.3

< 0.001**

SOD (U/ml)

136.0 ± 26.6

138.4 ± 30.3

134.8 ± 24.5

0.241

hsCRP (mg/L)

0.7 (0.3,1.8)

0.5 (0.3,1.5)

0.8 (0.3,2.0)

0.033*

ESR (mm/h)

17.0 (9.0,32.0)

16.5 (10.0,27.0)

19.0 (8.0,35.0)

0.647

IgA (g/L)

3.3 ± 1.1

3.3 ± 1.1

3.3 ± 1.2

0.695

IgM (g/L)

1.2 ± 0.6

1.3 ± 0.6

1.2 ± 0.5

0.024*

IgG (g/L)

11.5 ± 3.3

11.0 ± 3.5

11.7 ± 3.2

0.066

C3 (mg/L)

1054.2 ± 202.2

1077.9 ± 213.5

1042.0 ± 195.7

0.125

C4 (mg/L)

258.4 ± 91.6

250.9 ± 91.1

262.2 ± 91.9

0.288

Oxford classification, n (%)

 M1

320 (95.0)

108 (94.7)

212 (95.1)

0.896

 E1

65 (19.3)

15 (13.2)

50 (22.4)

0.041*

 S1

132 (39.2)

42 (36.8)

90 (40.4)

0.531

T

   

< 0.001**

 T0

238 (70.6)

106 (93.0)

132 (59.2)

 

 T1

70 (20.8)

7 (6.1)

63 (28.3)

 

 T2

29 (8.6)

1 (0.9)

28 (12.6)

 

C

   

0.524

 C0

150 (44.5)

54 (47.4)

96 (43.0)

 

 C1

166 (49.3)

55 (48.2)

111 (49.8)

 

 C2

21 (6.2)

5 (4.4)

16 (7.2)

 
  1. Abbreviations: Hcy homocysteine, SBP systolic blood pressure, DBP diastolic blood pressure, MAP mean arterial pressure, HBP Hypertension, Scr serum creatinine, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, BUN blood urine nitrogen, UA uric acid, Hb hemoglobin, ALB serum albumin, Glu fasting glucose, CHOL cholesterol, TG triglyceride, LDL low-density lipoprotein-cholesterol, HDL high-density lipoprotein-cholesterol, SOD superoxide dismutase, hsCRP high sensitivity C reaction protein, ESR erythrocyte sedimentatio rate, IgA immunoglobulin A, IgM immunoglobulin M, IgG immunoglobulin G, C3 complement3, C4 complement4, M mesangial hypercellularity, E endocapillary hypercellularity, S segmental glomerulosclerosis, T tubular atrophy and interstitial fibrosis, C crescents
  2. *P < 0.05, **P < 0.001
Back to article page

BMC Nephrology

ISSN: 1471-2369

Contact us